ZD7288 Chemical Properties

storage temp. 

Desiccate at +4°C

solubility 

Soluble in DMSO

form 

crystalline solid

ZD7288 Usage And Synthesis

Uses

ZD 7288 is a selective Ih channel inhibitor. ZD 7288 is an sino-atrial node function modulator; blocks the hyperpolarization activated cation current If. ZD 7288 blocks Ih in central neurons. ZD 7288 increases NMDA-evoked noradrenalin release in rat brain in vitro.

Biological Activity

Sino-atrial node function modulator; blocks the hyperpolarization activated cation current I f . Blocks I h in central neurons. Increases NMDA-evoked noradrenalin release in rat brain in vitro .

storage

Desiccate at +4°C

References

[1]. chen y, lin c, tang y, et al. zd 7288, an hcn channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats. world j gastroenterol, 2014, 20(8): 2091-2097.
[2]. sánchez-alonso jl, halliwell jv, colino a. zd 7288 inhibits t-type calcium current in rat hippocampal pyramidal cells. neurosci lett, 2008, 439(3): 275-280.
[3]. larkman pm, kelly js. modulation of the hyperpolarisation-activated current, ih, in rat facial motoneurones in vitro by zd-7288. neuropharmacology, 2001, 40(8): 1058-1072.
[4]. gasparini s, difrancesco d. action of the hyperpolarization-activated current (ih) blocker zd 7288 in hippocampal ca1 neurons. pflugers arch, 1997, 435(1): 99-106.

ZD7288(133059-99-1)Related Product Information

• N,N-Dimethylaniline
• N-Methylaniline
• N-Ethyl-3-methylaniline
• N,N-Dimethylcyclohexylamine
• N,N-DIMETHYLHYDROXYLAMINE HYDROCHLORIDE
• N,N'-Dimethyl-1,3-propanediamine
• N,N-Dimethylbenzylamine
• N-ethyl-propiolamide
• N-ethyl-4-(dimethylamino)benzylamine Dihydrochloride
• N-Ethylmethallylamine
• N-Ethyl-4-bromobenzylamine
• N-ETHYL-TETRAHYDRO-2H-PYRAN-4-AMINE
• N-Ethyl-D-glucamine
• N-Ethyl-N-chloroethyl-3-toluidine
• ZD7288
• 4,6-Pyrimidinediamine,2-methyl-
• pyrimidine-4,6-diamine hydrochloride