ZD7288
ZD7288 Basic information
- Product Name:
- ZD7288
- Synonyms:
-
- ICI D2788
- N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-Pyrimidinamine hydrochloride
- N-Ethyl-1,6-dihydro-1,2-diMethyl-6-(MethyliMino)- N-phenyl-4-pyriMidinaMine Monohydrochloride
- N-ethyl-1,2-dimethyl-6-methylimino-N-phenyl-pyrimidin-4-amine hydrochl oride
- ICI D7288
- inhibit,ICI D-7288,Hyperpolarization activated cyclic nucleotide gated channels,ICI D 7288,ZD 7288,HCN Channel,ZD7288,Inhibitor,ZD-7288
- CAS:
- 133059-99-1
- MF:
- C15H21ClN4
- MW:
- 0
- Product Categories:
-
- Ion Channels
- Amines
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 133059-99-1.mol
ZD7288 Chemical Properties
- storage temp.
- Desiccate at +4°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- color
- White to off-white
ZD7288 Usage And Synthesis
Uses
ZD 7288 is a selective Ih channel inhibitor. ZD 7288 is an sino-atrial node function modulator; blocks the hyperpolarization activated cation current If. ZD 7288 blocks Ih in central neurons. ZD 7288 increases NMDA-evoked noradrenalin release in rat brain in vitro.
Biological Activity
Sino-atrial node function modulator; blocks the hyperpolarization activated cation current I f . Blocks I h in central neurons. Increases NMDA-evoked noradrenalin release in rat brain in vitro .
storage
Desiccate at +4°C
References
[1]. chen y, lin c, tang y, et al. zd 7288, an hcn channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats. world j gastroenterol, 2014, 20(8): 2091-2097.
[2]. sánchez-alonso jl, halliwell jv, colino a. zd 7288 inhibits t-type calcium current in rat hippocampal pyramidal cells. neurosci lett, 2008, 439(3): 275-280.
[3]. larkman pm, kelly js. modulation of the hyperpolarisation-activated current, ih, in rat facial motoneurones in vitro by zd-7288. neuropharmacology, 2001, 40(8): 1058-1072.
[4]. gasparini s, difrancesco d. action of the hyperpolarization-activated current (ih) blocker zd 7288 in hippocampal ca1 neurons. pflugers arch, 1997, 435(1): 99-106.
ZD7288Supplier
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- sales@boylechem.com
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- 010-82848833 400-666-7788
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- 821-50328103-801 18930552037
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- 4401179829988
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- 021-50135380
- shchemsky@sina.com
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- ZD7288
- 4,6-Pyrimidinediamine,2-methyl-
- pyrimidine-4,6-diamine hydrochloride