ZD7288
- Product Name
- ZD7288
- CAS No.
- 133059-99-1
- Chemical Name
- ZD7288
- Synonyms
- ICI D2788;ICI D7288;N-ethyl-1,2-dimethyl-6-methylimino-N-phenyl-pyrimidin-4-amine hydrochl oride;N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-Pyrimidinamine hydrochloride;N-Ethyl-1,6-dihydro-1,2-diMethyl-6-(MethyliMino)- N-phenyl-4-pyriMidinaMine Monohydrochloride;inhibit,ICI D-7288,Hyperpolarization activated cyclic nucleotide gated channels,ICI D 7288,ZD 7288,HCN Channel,ZD7288,Inhibitor,ZD-7288
- CBNumber
- CB61074006
- Molecular Formula
- C15H21ClN4
- Formula Weight
- 0
- MOL File
- 133059-99-1.mol
ZD7288 Property
- storage temp.
- Desiccate at +4°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 15228
- Product name
- ZD 7288
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 15228
- Product name
- ZD 7288
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 15228
- Product name
- ZD 7288
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $286
- Updated
- 2024/03/01
- Product number
- 15228
- Product name
- ZD 7288
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $535
- Updated
- 2024/03/01
- Product number
- Z157500
- Product name
- ZD7288
- Packaging
- 100mg
- Price
- $1260
- Updated
- 2021/12/16
ZD7288 Chemical Properties,Usage,Production
Uses
ZD 7288 is a selective Ih channel inhibitor. ZD 7288 is an sino-atrial node function modulator; blocks the hyperpolarization activated cation current If. ZD 7288 blocks Ih in central neurons. ZD 7288 increases NMDA-evoked noradrenalin release in rat brain in vitro.
Biological Activity
Sino-atrial node function modulator; blocks the hyperpolarization activated cation current I f . Blocks I h in central neurons. Increases NMDA-evoked noradrenalin release in rat brain in vitro .
storage
Desiccate at +4°C
References
[1]. chen y, lin c, tang y, et al. zd 7288, an hcn channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats. world j gastroenterol, 2014, 20(8): 2091-2097.
[2]. sánchez-alonso jl, halliwell jv, colino a. zd 7288 inhibits t-type calcium current in rat hippocampal pyramidal cells. neurosci lett, 2008, 439(3): 275-280.
[3]. larkman pm, kelly js. modulation of the hyperpolarisation-activated current, ih, in rat facial motoneurones in vitro by zd-7288. neuropharmacology, 2001, 40(8): 1058-1072.
[4]. gasparini s, difrancesco d. action of the hyperpolarization-activated current (ih) blocker zd 7288 in hippocampal ca1 neurons. pflugers arch, 1997, 435(1): 99-106.
ZD7288 Preparation Products And Raw materials
Raw materials
Preparation Products
ZD7288 Suppliers
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View Lastest Price from ZD7288 manufacturers
- Product
- N-ethyl-1,2-dimethyl-6-methylimino-N-phenyl-pyrimidin-4-amine hydrochl oride 133059-99-1
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- ask
- Release date
- 2020-01-08