ZD-1611

Product Name: ZD-1611
CAS No.: 186497-38-1
Chemical Name: ZD-1611
Synonyms: ZD-1611;ZD 1611,ZD1611;Benzenepropanoic acid, 4-[3-[[(3-methoxy-5-methyl-2-pyrazinyl)amino]sulfonyl]-2-pyridinyl]-α,α-dimethyl-
CBNumber: CB03175606
Molecular Formula: C22H24N4O5S
Formula Weight: 456.52
MOL File: 186497-38-1.mol

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ZD-1611 Property

Boiling point:: 653.9±65.0 °C(Predicted)
Density: 1.339±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 4.62±0.13(Predicted)

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Hazard and Precautionary Statements (GHS)

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ZD-1611 Chemical Properties,Usage,Production

Uses

ZD-1611 is a potent, orally active, selective ETA receptor antagonist, used for the research of ischemic stroke.

in vivo

ZD1611 (0.3 mg/kg, p.o.) has a duration of action of more than 7 h in rats. In the dog, ZD1611 is active for at least 6 h at dose of 0.6 mg/kg p.o^[1]. ZD1611 (0.15 mg/kg/day) in combination with candesartan decreases the brain damage and improves the neurological scores in rats. However, ZD1611 or candesartan alone does not significantly decrease the brain damage or improve neurological scores^[2].

IC 50

ET_A

References

[1] Wilson C, et al. Pharmacological profile of ZD1611, a novel, orally active endothelin ETA receptor antagonist. J Pharmacol Exp Ther. 1999 Sep;290(3):1085-91. PMID:10454481
[2] Stenman E, et al. Cooperative effect of angiotensin AT(1) and endothelin ET(A) receptor antagonism limits the brain damage after ischemic stroke in rat. Eur J Pharmacol. 2007 Sep 10;570(1-3):142-8. Epub 2007 Jun 9. DOI:10.1016/j.ejphar.2007.05.049

ZD-1611 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZD-1611 Suppliers

China 5 United States 4 Global 9

MedChemexpress LLC

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Beijing Jin Ming Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Adooq Bioscience LLC

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TargetMol Chemicals Inc.

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186497-38-1, ZD-1611Related Search:

ZD-6888 3-[(4S)-5-OXO-2-(TRIFLUOROMETHYL)-1,4,5,6,7,8-HEXAHYDROQUINOLIN-4-YL]BENZONITRILE ICI D2138 ZD-4190 N-(4-METHOXYBENZOYL)-L-VALYL]-N-[(1S)-3,3,3-TR IFLUOR-1-ISOPROPYL2-OXOPROPYL]-L-PROLINAMIDE ZD7288 ICI D 6888 ZD 9379

ZD-1611

Benzenepropanoic acid, 4-[3-[[(3-methoxy-5-methyl-2-pyrazinyl)amino]sulfonyl]-2-pyridinyl]-α,α-dimethyl-

ZD 1611,ZD1611

186497-38-1