3-[(4S)-5-OXO-2-(TRIFLUOROMETHYL)-1,4,5,6,7,8-HEXAHYDROQUINOLIN-4-YL]BENZONITRILE
- Product Name
- 3-[(4S)-5-OXO-2-(TRIFLUOROMETHYL)-1,4,5,6,7,8-HEXAHYDROQUINOLIN-4-YL]BENZONITRILE
- CAS No.
- 172649-40-0
- Chemical Name
- 3-[(4S)-5-OXO-2-(TRIFLUOROMETHYL)-1,4,5,6,7,8-HEXAHYDROQUINOLIN-4-YL]BENZONITRILE
- Synonyms
- ZD0947;AZD0947;AZD-0947;AZD 0947;ZD0947 >=98% (HPLC);(S)-3-(5-Oxo-2-(trifluoromethyl)-1,4,5,6,7,8-hexahydroquinolin-4-yl)benzonitrile;3-[(4S)-5-OXO-2-(TRIFLUOROMETHYL)-1,4,5,6,7,8-HEXAHYDROQUINOLIN-4-YL]BENZONITRILE;Benzonitrile, 3-[(4S)-1,4,5,6,7,8-hexahydro-5-oxo-2-(trifluoromethyl)-4-quinolinyl]-
- CBNumber
- CB21478653
- Molecular Formula
- C17H13F3N2O
- Formula Weight
- 318.29
- MOL File
- 172649-40-0.mol
3-[(4S)-5-OXO-2-(TRIFLUOROMETHYL)-1,4,5,6,7,8-HEXAHYDROQUINOLIN-4-YL]BENZONITRILE Property
- Boiling point:
- 420.4±45.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 2mg/mL, clear
- pka
- -0.32±0.60(Predicted)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D -625 to -575°, c =0.5 in methanol
N-Bromosuccinimide Price
- Product number
- SML2055
- Product name
- ZD0947
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $109.25
- Updated
- 2025/07/31
- Product number
- SML2055
- Product name
- ZD0947
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $371
- Updated
- 2025/07/31
- Product number
- HCH0130246
- Product name
- 3-[(4S)-5-OXO-2-(TRIFLUOROMETHYL)-1,4,5,6,7,8-HEXAHYDROQUINOLIN-4-YL]BENZONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.38
- Updated
- 2021/12/16
3-[(4S)-5-OXO-2-(TRIFLUOROMETHYL)-1,4,5,6,7,8-HEXAHYDROQUINOLIN-4-YL]BENZONITRILE Chemical Properties,Usage,Production
Uses
ZD0947 is an ATP-sensitive potassium channel activator with relatively effective activation of smooth muscle KATP channels (SUR2B/Kir6.1 and SUR2B/Kir6.2). ZD0947 partially antagonizes pancreatic KATP channels (SUR1/Kir6.2) and cardiac KATP channels (SUR2A/Kir6.2). ZD0947 is potentially used to inhibit overactive bladder (OAB)[1].
Biological Activity
ZD0947 is potent ATP-sensitive K+ channels (KATP channels) opener. ZD0947 is an effective activator of smooth muscle-type KATP channels (SUR2B/Kir6.1 and SUR2B/Kir6.2) but is a partial antagonist of pancreatic-type KATP channels (i.e. SUR1/Kir6.2) and cardiac-type KATP channels (i.e. SUR2A/Kir6.2). ZD0947 potently inhibits carbacho-induced contraction in the strips of human detrusor.
References
[1] Effects of ZD0947, a novel and potent ATP-sensitive K+ channel opener, on smooth muscle-type ATP-sensitive K+ channels DOI:10.1016/j.ejphar.2016.09.038
3-[(4S)-5-OXO-2-(TRIFLUOROMETHYL)-1,4,5,6,7,8-HEXAHYDROQUINOLIN-4-YL]BENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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