ZD7288

Product Name: ZD7288
CAS No.: 133059-99-1
Chemical Name: ZD7288
Synonyms: ICI D2788;ICI D7288;N-ethyl-1,2-dimethyl-6-methylimino-N-phenyl-pyrimidin-4-amine hydrochl oride;N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-Pyrimidinamine hydrochloride;N-Ethyl-1,6-dihydro-1,2-diMethyl-6-(MethyliMino)- N-phenyl-4-pyriMidinaMine Monohydrochloride;inhibit,ICI D-7288,Hyperpolarization activated cyclic nucleotide gated channels,ICI D 7288,ZD 7288,HCN Channel,ZD7288,Inhibitor,ZD-7288
CBNumber: CB61074006
Molecular Formula: C15H21ClN4
Formula Weight: 0
MOL File: 133059-99-1.mol

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ZD7288 Property

storage temp.: Desiccate at +4°C
solubility: Soluble in DMSO
form: crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15228
Product name: ZD 7288
Purity: ≥98%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 15228
Product name: ZD 7288
Purity: ≥98%
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 15228
Product name: ZD 7288
Purity: ≥98%
Packaging: 25mg
Price: $286
Updated: 2024/03/01

Cayman Chemical

Product number: 15228
Product name: ZD 7288
Purity: ≥98%
Packaging: 50mg
Price: $535
Updated: 2024/03/01

TRC

Product number: Z157500
Product name: ZD7288
Packaging: 100mg
Price: $1260
Updated: 2021/12/16

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ZD7288 Chemical Properties,Usage,Production

Uses

ZD 7288 is a selective Ih channel inhibitor. ZD 7288 is an sino-atrial node function modulator; blocks the hyperpolarization activated cation current If. ZD 7288 blocks Ih in central neurons. ZD 7288 increases NMDA-evoked noradrenalin release in rat brain in vitro.

Biological Activity

Sino-atrial node function modulator; blocks the hyperpolarization activated cation current I f . Blocks I h in central neurons. Increases NMDA-evoked noradrenalin release in rat brain in vitro .

storage

Desiccate at +4°C

References

[1]. chen y, lin c, tang y, et al. zd 7288, an hcn channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats. world j gastroenterol, 2014, 20(8): 2091-2097.
[2]. sánchez-alonso jl, halliwell jv, colino a. zd 7288 inhibits t-type calcium current in rat hippocampal pyramidal cells. neurosci lett, 2008, 439(3): 275-280.
[3]. larkman pm, kelly js. modulation of the hyperpolarisation-activated current, ih, in rat facial motoneurones in vitro by zd-7288. neuropharmacology, 2001, 40(8): 1058-1072.
[4]. gasparini s, difrancesco d. action of the hyperpolarization-activated current (ih) blocker zd 7288 in hippocampal ca1 neurons. pflugers arch, 1997, 435(1): 99-106.

ZD7288 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZD7288 Suppliers

China 29 Germany 1 India 1 United Kingdom 4 United States 7 USA 1 Global 43

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View Lastest Price from ZD7288 manufacturers

Career Henan Chemical Co

Product: N-ethyl-1,2-dimethyl-6-methylimino-N-phenyl-pyrimidin-4-amine hydrochl oride 133059-99-1
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

133059-99-1, ZD7288Related Search:

N,N-Dimethylaniline N-Methylaniline N-Ethyl-3-methylaniline N,N-Dimethylcyclohexylamine N,N-DIMETHYLHYDROXYLAMINE HYDROCHLORIDE N,N'-Dimethyl-1,3-propanediamine N,N-Dimethylbenzylamine N-ethyl-propiolamide N-ethyl-4-(dimethylamino)benzylamine Dihydrochloride N-Ethylmethallylamine N-Ethyl-4-bromobenzylamine N-ETHYL-TETRAHYDRO-2H-PYRAN-4-AMINE N-Ethyl-D-glucamine N-Ethyl-N-chloroethyl-3-toluidine ZD7288 4,6-Pyrimidinediamine,2-methyl- pyrimidine-4,6-diamine hydrochloride

ICI D2788

N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-Pyrimidinamine hydrochloride

N-Ethyl-1,6-dihydro-1,2-diMethyl-6-(MethyliMino)- N-phenyl-4-pyriMidinaMine Monohydrochloride

N-ethyl-1,2-dimethyl-6-methylimino-N-phenyl-pyrimidin-4-amine hydrochl oride

ICI D7288

inhibit,ICI D-7288,Hyperpolarization activated cyclic nucleotide gated channels,ICI D 7288,ZD 7288,HCN Channel,ZD7288,Inhibitor,ZD-7288

133059-99-1

C15H20N4HCl

C15H21ClN4

Ion Channels

Amines

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals