ChemicalBook > CAS DataBase List > ZD7288

ZD7288

Product Name
ZD7288
CAS No.
133059-99-1
Chemical Name
ZD7288
Synonyms
ICI D2788;ICI D7288;N-ethyl-1,2-dimethyl-6-methylimino-N-phenyl-pyrimidin-4-amine hydrochl oride;N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-Pyrimidinamine hydrochloride;N-Ethyl-1,6-dihydro-1,2-diMethyl-6-(MethyliMino)- N-phenyl-4-pyriMidinaMine Monohydrochloride;inhibit,ICI D-7288,Hyperpolarization activated cyclic nucleotide gated channels,ICI D 7288,ZD 7288,HCN Channel,ZD7288,Inhibitor,ZD-7288
CBNumber
CB61074006
Molecular Formula
C15H21ClN4
Formula Weight
0
MOL File
133059-99-1.mol
More
Less

ZD7288 Property

storage temp. 
Desiccate at +4°C
solubility 
Soluble in DMSO
form 
crystalline solid
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
15228
Product name
ZD 7288
Purity
≥98%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
15228
Product name
ZD 7288
Purity
≥98%
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
15228
Product name
ZD 7288
Purity
≥98%
Packaging
25mg
Price
$286
Updated
2024/03/01
Cayman Chemical
Product number
15228
Product name
ZD 7288
Purity
≥98%
Packaging
50mg
Price
$535
Updated
2024/03/01
TRC
Product number
Z157500
Product name
ZD7288
Packaging
100mg
Price
$1260
Updated
2021/12/16
More
Less

ZD7288 Chemical Properties,Usage,Production

Uses

ZD 7288 is a selective Ih channel inhibitor. ZD 7288 is an sino-atrial node function modulator; blocks the hyperpolarization activated cation current If. ZD 7288 blocks Ih in central neurons. ZD 7288 increases NMDA-evoked noradrenalin release in rat brain in vitro.

Biological Activity

Sino-atrial node function modulator; blocks the hyperpolarization activated cation current I f . Blocks I h in central neurons. Increases NMDA-evoked noradrenalin release in rat brain in vitro .

storage

Desiccate at +4°C

References

[1]. chen y, lin c, tang y, et al. zd 7288, an hcn channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats. world j gastroenterol, 2014, 20(8): 2091-2097.
[2]. sánchez-alonso jl, halliwell jv, colino a. zd 7288 inhibits t-type calcium current in rat hippocampal pyramidal cells. neurosci lett, 2008, 439(3): 275-280.
[3]. larkman pm, kelly js. modulation of the hyperpolarisation-activated current, ih, in rat facial motoneurones in vitro by zd-7288. neuropharmacology, 2001, 40(8): 1058-1072.
[4]. gasparini s, difrancesco d. action of the hyperpolarization-activated current (ih) blocker zd 7288 in hippocampal ca1 neurons. pflugers arch, 1997, 435(1): 99-106.

ZD7288 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

View Lastest Price from ZD7288 manufacturers

Career Henan Chemical Co
Product
N-ethyl-1,2-dimethyl-6-methylimino-N-phenyl-pyrimidin-4-amine hydrochl oride 133059-99-1
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

133059-99-1, ZD7288Related Search:


  • ICI D2788
  • N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-Pyrimidinamine hydrochloride
  • N-Ethyl-1,6-dihydro-1,2-diMethyl-6-(MethyliMino)- N-phenyl-4-pyriMidinaMine Monohydrochloride
  • N-ethyl-1,2-dimethyl-6-methylimino-N-phenyl-pyrimidin-4-amine hydrochl oride
  • ICI D7288
  • inhibit,ICI D-7288,Hyperpolarization activated cyclic nucleotide gated channels,ICI D 7288,ZD 7288,HCN Channel,ZD7288,Inhibitor,ZD-7288
  • 133059-99-1
  • C15H20N4HCl
  • C15H21ClN4
  • Ion Channels
  • Amines
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals