Brinazarone
Brinazarone Basic information
- Product Name:
- Brinazarone
- Synonyms:
-
- Brinazarone
- SR 33287
- Methanone, [4-[3-[(1,1-dimethylethyl)amino]propoxy]phenyl][2-(1-methylethyl)-3-indolizinyl]-
- CAS:
- 89622-90-2
- MF:
- C25H32N2O2
- MW:
- 392.53
- Mol File:
- 89622-90-2.mol
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Brinazarone Chemical Properties
- Density
- 1.06±0.1 g/cm3(Predicted)
- pka
- 10.47±0.10(Predicted)
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Brinazarone Usage And Synthesis
Uses
Brinazarone (SR 33287) is an inhibitor for acid lysosomal sphingomyelinase, and leads to cellular lipidosis. Brinazarone potentiates the cytotoxic effects of anti-Thy 1.2 AT15E RTA-IT on T2 cells and anti-CD5 T101 on CEM cells[1].
References
[1] Jaffrézou JP, et al., In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction. Cancer Res. 1992 Mar 1;52(5):1352-9. PMID:1737397