Basic information testosterone Pharmacokinetics Uses Indications and Dosages Side effects overdose Related Articles Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Hormones and the Endocrine System >  Androgen and anabolic hormones >  Oxandrolone

Oxandrolone

Basic information testosterone Pharmacokinetics Uses Indications and Dosages Side effects overdose Related Articles Safety Supplier Related

Oxandrolone Basic information

Product Name:
Oxandrolone
Synonyms:
  • ceticaciddelta-lactone
  • dodecahydro-3-hydroxy-6-(hydroxy-methyl)-3,3a,6-trimethyl-1h-benz[e]indene-7-a
  • Lonavar
  • NSC-67068
  • Protivar
  • Provitar
  • SC 11585
  • sc11585
CAS:
53-39-4
MF:
C19H30O3
MW:
306.44
EINECS:
200-172-9
Product Categories:
  • Inhibitors
  • anavar
  • Miscellaneous
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroid and Hormone
  • Biochemistry
  • Steroids
  • Steroids (Others)
  • Finished Steroid and Hormone
Mol File:
53-39-4.mol
More
Less

Oxandrolone Chemical Properties

Melting point:
235-238°C
alpha 
D25 -23° (c = approx 1% in chloroform)
Boiling point:
387.04°C (rough estimate)
Density 
1.0829 (rough estimate)
refractive index 
1.4200 (estimate)
storage temp. 
Controlled Substance, -20?C Freezer
solubility 
DMSO: soluble2mg/mL (clear solution; warmed)
pka
15.15±0.60(Predicted)
form 
powder
color 
white to beige
optical activity
[α]/D -19 to -26°, c = 1 (CDCl3)
Merck 
6921
InChIKey
QSLJIVKCVHQPLV-PEMPUTJUSA-N
CAS DataBase Reference
53-39-4(CAS DataBase Reference)
NIST Chemistry Reference
Oxandrolone(53-39-4)
More
Less

Safety Information

Hazard Codes 
T
Risk Statements 
60-63-20/21/22
Safety Statements 
22-36/37/39-45
WGK Germany 
3
RTECS 
RN6800700
HS Code 
2937290000
Hazardous Substances Data
53-39-4(Hazardous Substances Data)
Toxicity
LD50 oral in rabbit: > 5gm/kg
More
Less

Oxandrolone Usage And Synthesis

testosterone

Oxandrolone is an anabolic steroid, a testosterone analog with ten times the anabolic activity but one-tenth of the androgenic activity of testosterone. Research into its use in burn injury for preventing loss or restoring muscle mass has been going on since the mid-1990s. Demling found that patients in the rehabilitation phase on an exercise programme, oxan- drolone and a high protein diet gained more body weight than those on an exercise programme and normal or high protein diet. Oxandrolone was effective in older adults, over 60 years, as well as in younger adults. This is important in light of the difficulties older adults face due to loss of lean body mass.

In 2000 Demling used oxandrolone (20 mg/ day) in the acute phase on burn injury, beginning when patients reached a minimum of 75% of their energy and protein requirements. Twenty patients were studied in a double-blind randomised controlled trial. Patients on oxandrolone had an improved net nitrogen balance, decreased weight loss, faster healing of donor sites and a shorter length of stay. Oxandrolone did not decrease metabolic rate and there were no side effects. The use of oxandralone is being considered in burns in the UK.

Pharmacokinetics

Oxandrolone is administered orally and is rapidly absorbed. Oxandrolone is highly bound (9–97%) to plasma proteins and has a bioavailability of approximately 97%. Hepatic metabolism of oxandrolone is markedly slower than that of testosterone or other androgens due to the modification of ring A (lack of a 4-ene function) and 17alfa-alkylation. The elimination half-life for oxandrolone is approximately 9.4 h, and peak plasma concentrations are higher than methyltestosterone. Oxandrolone is excreted primarily in the urine as the unchanged parent drug (approximately 28%) and unconjugated product.

Uses

The use of oxandrolone, an analog of testosterone possessing only 5% of testosterone's virilizing androgenic effects, enhances anabolism of muscle protein by improving the efficiency of protein synthesis in severely burned children. Oxandrolone administration decreases loss of body weight and improves healing of the donor site wound. In a large clinical trial by our group, 0.1 mg/kg oxandrolone administered twice daily reduced length of the acute hospitalization, sustained LBM, and improved liver protein synthesis. Severely burned pediatric patients receiving oxandrolone for 1 year experienced improved growth, decreased cardiac work, and improved muscle strength. Oxandrolone treatment also improved lung function at rest and during exercise in this patient population. These improvements were maintained for up to 4 years after treatment had ended. The benefits of oxandrolone administration after burn injury were further enhanced when the treatment period was increased from 1 to 2 years.

Indications and Dosages

It is important to note that when treating wasting conditions with oxandrolone (or any other androgen), proper nutrition is essential. Oxandrolone is indicated for the treatment of wasting syndromes associated with chronic diseases and lack of nutrition. Oxandrolone has also been suggested for use in the treatment of AIDS-related wasting syndrome, Duchenne muscular dystrophy, growth failure, and Turner’s syndrome. However, these uses have not been approved by the FDA. Oxandrolone is indicated for treating wasting conditions (cachexia, resulting from chronic disease and/or infection, severe trauma, prolonged glucocorticoid treatment, or extensive surgery), thereby promoting weight gain and increased protein synthesis. Furthermore, treatment would be indicated within those individuals who fail to maintain normal body weight. The usual recommended oral dosage in adults is 2.5 mg, taken 2-4 times daily (5-10 mg/day) over a period of 2-4 weeks. Depending on how the patient responds, the treatment may be repeated as needed. If necessary, the dosage may be increased up to 20 mg/day. However, the patient’s response to treatment will determine the dose and duration of treatment. In children, the recommended oral dose is 0.1 mg/kg (0.045 mg/pound) body weight/day over a period of 2–4 weeks. However, the dosage should not exceed the adult dosage.

Side effects

No significant side effects have been reported in boys treated with oxandrolone for CDGD. Although oxandrolone has significantly fewer androgenic effects than testosterone, mild virilization has been reported in girls taking oxandrolone, including clitoromegaly. This is less of a concern at lower doses. There are also reports of a delay in breast development that improves upon higher estrogen dosing. Hepatic dysfunction has been reported with oxandrolone treatment, manifested by alterations in HDL cholesterol, and thus monitoring of lipids is suggested.

overdose

No symptoms or signs associated with overdosage have been reported. It is possible that sodium and water retention may occur.
The oral LD50 of oxandrolone in mice and dogs is greater than 5,000 mg/kg. No specific antidote is known, but gastric lavage may be used.

Related Articles

Oxandrolone is a man-made steroid, similar to the naturally occurring steroid testosterone. Oxandrolone is an "anabolic" steroid that promotes the growth of muscle tissue.
https://www.drugs.com/mtm/oxandrolone.html
Oxandrolone is a synthetic, orally active anabolic-androgenic steroid. Oxandrolones interact with androgen receptors in target tissues.
https://drugs.ncats.io/substance/7H6TM3CT4L
Oxandrolone is an anabolic steroid that has been used in catabolic situations such as hepatitis and AIDS patients and can be administered orally, thus eliminating one source of stress for children and families.
https://www.sciencedirect.com/topics/neuroscience/oxandrolone
Oxandrin (oxandrolone) is indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight, to offset the protein catabolism associated with prolonged administration of corticosteroids, and for the relief of the bone pain frequently accompanying osteoporosis (See DOSAGE AND ADMINISTRATION).
https://www.rxlist.com/oxandrin-drug.htm#indications

Description

Oxandrolone is a synthetic anabolic-androgenic steroid. It is a 17 alpha-methylated version of dihydrotestosterone (DHT). It can be used for the treatment of many kinds of disorders such as idiopathic short stature, body mass loss due to catabolic illness, severe burns, trauma and hereditary angioedema as well as turner syndrome. Oxandrolone is especially effective in the treatment of severe burns without causing obvious side effects. It acts as an agonist of the androgen receptor, which modulates related gene expression to increase protein synthesis, further boosting muscle growth and increasing body mass as well as bone mineral density. However, it should be noted that its androgenic effect is less than its anabolic effect.

Chemical Properties

White Solid

Originator

Anavar,Searle,US,1964

Uses

androgenic anabolic steroid;reverses catabolic tissue processes; promotes buildup of protein; increases erythropoietin production

Uses

A synthetic, anabolic steroid. Used to promote muscle growth and combat involuntary weight loss. It has also been used to treat cases of osteoporosis.

Manufacturing Process

To a solution of 6.36 parts of 17β-hydroxy-17α-methyl-5α-androst-1-en-3-one in 95 parts of acetic acid and 12 parts of water is added 40 parts of lead tetracetate and 0.6 part of osmium tetroxide. This mixture is stored at room temperature for about 24 hours, then is treated with 2 parts of lead tetracetate. Evaporation to dryness at reduced pressure affords a residue, which is extracted with benzene. The benzene extract is washed with water, and extracted with aqueous potassium bicarbonate. The aqueous extract is washed with ether, acidified with dilute sulfuric acid, then extracted with ethyl acetate-benzene. This organic extract is washed with water, dried over anhydrous sodium sulfate, and concentrated to dryness in vacuo. To a solution of the residual crude product in 20 parts of pyridine is added 10 parts of 20% aqueous sodium bisulfite and the mixture is stirred for about 20 minutes at room temperature
This mixture is then diluted with water, washed with ethyl acetate, acidified with dilute sulfuric acid, and finally extracted with benzene. The benzene extract is washed with water, dried over anhydrous sodium sulfate, and evaporated to dryness at reduced pressure to produce crude 17β-hydroxy17α-methyl-1-oxo-1,2-seco-A-nor-5α-androstan-2-oic acid, which after recrystallization from aqueous isopropyl alcohol melts at about 166° to 173°C (decomposition).
An aqueous slurry of 6 parts of 17β-hydroxy-17α-methyl-1-oxo-1,2-seco-Anor-5α-androstan-2-oic acid in 200 parts of water is made alkaline to pH 10 by the addition of dilute aqueous sodium hydroxide, then is treated with 6 parts of sodium borohydride. This mixture is allowed to react at room temperature for about 3 hours. Benzene is added and the resulting mixture is acidified carefully with dilute hydrochloric acid. The benzene layer is separated, and the aqueous layer is further extracted with benzene. The combined benzene extracts are washed successively with aqueous potassium bicarbonate and water, dried over anhydrous sodium sulfate, then evaporated to dryness in vacuo. The resulting residue is triturated with ether to afford pure 17β-hydroxy-17α-methyl-2-oxa-5α-androstan-3-one, MP about 235° to 238°C, according to US Patent 3,128,283.

brand name

Oxandrin (Savient).

Therapeutic Function

Androgen

General Description

Oxandrolone, 17β-hydroxy-17-methyl-2-oxaandrostan-3-one, is approved to aid in the promotionof weight gain after weight loss following surgery,chronic infections, or severe trauma and to offset protein catabolismassociated with long-term corticosteroid use.Oxandrolone is also used to relieve bone pain accompanyingosteoporosis. It has been used to treat alcoholic hepatitisand HIV wasting syndrome.

Safety Profile

Moderately toxic by ingestion andintraperitoneal routes. Experimental reproductive effects.When heated to decomposition it emits acrid smoke andfumes.

Chemical Synthesis

Oxandrolone, 17β-hydroxy-17α-methyl-2-oxa-5-androstan-3-one (29.3.10), is made by oxidation of the C1–C2 double bond of 17β-hydroxy-17α-methyl-1-androsten- 3-one by a mixture of lead tetraacetate and osmium tetroxide with an opening of the A ring of the steroid system, which forms an aldehyde acid (29.3.9). Upon reducing the aldehyde group with sodium borohydride, intramolecular cyclization takes place, directly forming a lactone (29.3.10), which is the desired oxandrolone.

References

Li, H., et al. "The efficacy and safety of oxandrolone treatment for patients with severe burns: A systematic review and meta-analysis. " Burns Journal of the International Society for Burn Injuries 42.4(2016): 717.
Hart, D. W., et al. "Anabolic effects of oxandrolone after severe burn." Annals of Surgery 233.4(2001): 556-564.
Sheffieldmoore, M, et al. "Short-term oxandrolone administration stimulates net muscle protein synthesis in young men. " Journal of Clinical Endocrinology & Metabolism 84.8(1999): 2705-11.
https://en.wikipedia.org/wiki/Oxandrolone

OxandroloneSupplier

HuBei ShengBaoLai Biological Technology Co., Ltd Gold
Tel
027-59105235-
Email
sbl1120@163.com;2547724091@qq.com;
Wuhan Biocar Bio-Pharm Co., Ltd. Gold
Tel
86 15387057351
Email
sales@biocar.cn
Shanghai Boyle Chemical Co., Ltd.
Tel
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Email
sales@boylechem.com
INTATRADE GmbH
Tel
+49 3493/605464
Email
sales@intatrade.de
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com