ANTI-BRAIN DERIVED NEUROTROPHIC FACTOR Chemical Properties

storage temp. 

-20°C

form 

lyophilized powder

biological source

rabbit

Safety Information

WGK Germany 

3

Storage Class

13 - Non Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich

ANTI-BRAIN DERIVED NEUROTROPHIC FACTOR Usage And Synthesis

Uses

Anti-BDNF antibody produced in rabbit has been used in immunohistochemistry and western blotting.

Uses

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .

General Description

The antibody shows ~5% cross-reactivity with recombinant human βNGF and recombinant rat βNGF.

Biochem/physiol Actions

Brain derived neurotrophic factor (BDNF) is involved in hippocampal function and verbal episodic memory in humans. Hence, variation in the BDNF gene expression alters these neurological functions. BDNF also plays a vital role in vascular function and participates in angiogenesis via the specific receptor tropomyosin-related kinase B (TrkB). It is involved in the pathogenesis of Alzheimer′s disease. ProBDNF interacts with p75 neurotrophin receptor, leading to long-term depression in the hippocampus.

ANTI-BRAIN DERIVED NEUROTROPHIC FACTOR()Related Product Information

• BDNF(human)