Lutropinalfa Usage And Synthesis

Uses

Lutropin is a heterodimeric glycoprotein, a hormone produced by gonadotropic cells in the anterior pituitary gland, also known as luteinizing hormone and lutrophin. Lutropin stimulates follicular development, and can be used for researching infertility[1][2].

Clinical Use

Lutropin alfa is the first pure human LH preparation and is of rDNA origin. According to physicochemical and biological assays, it is indistinguishable from human LH of natural origin. It is indicated for use in infertile women who are undergoing ART, specifically those with severe LH deficiency. It is meant to be coadministered with follitropin alfa so as to stimulate follicular growth in these women. When the follicles are of correct size, as determined by ultrasound examination, hCG would be administered to stimulate ovulation.

References

[1] Ezcurra D, et al. A review of luteinising hormone and human chorionic gonadotropin when used in assisted reproductive technology. Reprod Biol Endocrinol. 2014 Oct 3;12:95. DOI:10.1186/1477-7827-12-95
[2] Stamatiades GA, et al. Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression. Mol Cell Endocrinol. 2018 Mar 5;463:131-141. DOI:10.1016/j.mce.2017.10.015