Solifenacin Hydrochloride
Solifenacin Hydrochloride Basic information
- Product Name:
- Solifenacin Hydrochloride
- Synonyms:
-
- Vesicare hydrochloride
- VESICARE HYDROCHLORIDE;YM905 HYDROCHLORIDE;YM 905 HYDROCHLORIDE;YM-905 HYDROCHLORIDE
- YM 905 hydrochloride
- YM905 hydrochloride
- YM-905 hydrochloride
- (1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic Acid (3R)-1-Azabicyclo-[2.2.2]oct-3-yl Ester Hydrochlorid
- (1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic acid (3R)-1-azabicyclo[2.2.2]oct-3-yl ester hydrochloride (1:1)
- Solifenacin Hydrochloride
- CAS:
- 180468-39-7
- MF:
- C23H27ClN2O2
- MW:
- 398.93
- Product Categories:
-
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 180468-39-7.mol
Solifenacin Hydrochloride Chemical Properties
- Melting point:
- 120-122°C
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
Solifenacin Hydrochloride Usage And Synthesis
Chemical Properties
White Solid
Uses
Muscarinic M3 receptor antagoinst used in treatment of urinary incontinence.
Uses
Solifenacin Hydrochloride can be used as muscarinic M3 receptor antagoinst and used in treatment of urinary incontinence
in vivo
Solifenacin hydrochloride (YM905 hydrochloride) reduces bladder responses by 40% at a dose of 210 nmol/kg (0.1 mg/kg) and abolishes them at 2100 nmol/kg (1 mg/kg). In contrast, its inhibitory effects on salivary and cardiac responses are only slight at 630 nmol/kg (0.3 mg/kg), and reach 66% and 49%, respectively, at 2100 nmol/kg (1 mg/kg). At doses of 63 and 210 nmol/kg (0.03 and 0.1 mg/kg), Solifenacin hydrochloride slightly increases saliva secretion[1]. Solifenacin hydrochloride (0.01 to 0.3 mg/kg i.v.) dose-dependently increases bladder capacity and voided volume at doses of 0.03 mg/kg i.v. or more, but does not affect residual volume or micturition pressure at any dose tested[2].
IC 50
mAChR2; mAChR1; mAChR3
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