Basic information Safety Supplier Related

Clocapramine

Basic information Safety Supplier Related

Clocapramine Basic information

Product Name:
Clocapramine
Synonyms:
  • 3-chlorocarpipramine
  • 1'-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl][1,4'-bipiperidine]-4'-carboxamide
  • 1-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-4-piperidino-4-piperidinecarboxamide
  • 28058-62-0 (Di-hydrochloride)
  • 65016-29-7 (Di-hydrochloride monohydrate)
  • Clocapramina
  • Clocapramina [inn-spanish]
  • Clocapraminum
CAS:
47739-98-0
MF:
C28H37ClN4O
MW:
481.07
Mol File:
47739-98-0.mol
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Clocapramine Chemical Properties

Boiling point:
662.1±55.0 °C(Predicted)
Density 
1.23 g/cm3
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
16.20±0.20(Predicted)
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Clocapramine Usage And Synthesis

Uses

Clocapramine is an antagonist of the D2, 5-HT2A receptors.

Definition

ChEBI: Clocapramine is a dibenzooxazepine.

in vivo

Clocapramine shows the lowest potency for D2-occupancy in vivo[1]. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D2 and frontal serotonin-5-HT2 receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT2 versus D2 receptors that fall between these two groups (ED50 of 14.5 mg/kg for D2, 4.9 mg/kg for 5-HT2)[2].

IC 50

D2 Receptor; 5-HT2A Receptor

References

[1] Schotte A, et al. In vitro receptor binding and in vivo receptor occupancy in rat and guinea pig brain: risperidone compared with antipsychotics hitherto used. Jpn J Pharmacol. 1995 Dec;69(4):399-412. DOI:10.1254/jjp.69.399
[2] Sumiyoshi T, et al. Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy. Neuropsychopharmacology. 1995 Feb;12(1):57-64. DOI:10.1038/sj.npp.1380239

ClocapramineSupplier

Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
cjbscvictory
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13348960310
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Nantong QuanYi Biotechnology Co., Ltd
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0513-66337626 18051384581
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sales@chemhifuture.com
RD International Technology Co., Limited
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18024082417
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market@ubiochem.com
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