N-(1-oxopropyl)-Glycine Chemical Properties

Melting point:

126-127 °C

Boiling point:

382.6±25.0 °C(Predicted)

Density 

1.174±0.06 g/cm3(Predicted)

storage temp. 

Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

3.60±0.10(Predicted)

color 

White to Off-White

Safety Information

HazardClass 

IRRITANT

N-(1-oxopropyl)-Glycine Usage And Synthesis

Uses

A metabolite of methylmalonic acid and propionic acid in children with methylmalonic acid and propionic acid metabolic disorders.

Definition

ChEBI: A N-acylglycine obtained by formal condensation of the carboxy group of propionic acid with the amino group of glycine.

Biological Activity

Propionylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme th at catalyzes the chemical reaction:acyl-CoA + glycine < -- > CoA + N-acylglycine. The level of propionylglycine is elevated in patients with propionic acidemia, which is an inherited deficiency of propionyl-CoA carboxylase.

N-(1-oxopropyl)-Glycine(21709-90-0)Related Product Information

• Zinc glycinate
• Trimethylglycine