(R)-Flecainide
(R)-Flecainide Basic information
- Product Name:
- (R)-Flecainide
- Synonyms:
-
- (R)-(-)-Flecainide
- (R)-Flecainide
- Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, (R)-
- Benzamide, N-[(2R)-2-piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)-
- N-[(2R)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
- N-[(R)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
- N-[[(2R)-piperidin-2-yl]methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
- CAS:
- 99495-90-6
- MF:
- C17H20F6N2O3
- MW:
- 414.34
- Product Categories:
-
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 99495-90-6.mol
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(R)-Flecainide Chemical Properties
- Boiling point:
- 434.9±45.0 °C(Predicted)
- Density
- 1.286±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Ethanol: soluble; Methanol: soluble
- form
- A solid
- pka
- 14.15±0.46(Predicted)
- color
- White to off-white
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(R)-Flecainide Usage And Synthesis
Description
R-(–)-Flecainide is the (R) enantiomer of the antiarrhythmic agent flecainide . R-(–)-Flecainide prevents chloroform-induced ventricular fibrillation in mice (ED50 = 14.5 mg/kg). It also prevents ouabain-induced ectopic ventricular tachycardia in anesthetized dogs.
Uses
R-Enantiomer of Flecainide. Antiarrhythmic (class IC).
in vivo
R-(–)-Flecainide inhibits chloroform-induced fibrillation (9-20 mg/kg, po, single dose) in mice model with an ED50 of 14.5 mg/kg, and inhibits ouabain induced arrhythmias (1-3 mg/kg, ) in mongrel dog model, without toxicity[1].
| Animal Model: | Chloroform-induced ventricular fibrillation in mice[1] |
| Dosage: | 9-20 mg/kg |
| Administration: | po, single dose |
| Result: | Prevented fibrillation. |
| Animal Model: | Ouabain induced ventricular tachycardia in mongrel dog[1] |
| Dosage: | 1-3 mg/kg |
| Administration: | iv, single dose |
| Result: | Inhibited arrhythmias. |
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