ACYCLOVIR-D4 Chemical Properties

Melting point:

>245°C dec.

storage temp. 

-20°C Freezer

solubility 

DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)

form 

Solid

color 

White to Pale Beige

Stability:

Hygroscopic

ACYCLOVIR-D4 Usage And Synthesis

Description

Acyclovir-d₄ is intended for use as an internal standard for the quantification of acyclovir by GC- or LC-MS. Acyclovir is a guanosine analog that has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID₅₀s = 0.1-63.1 μM). It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity. Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.

Chemical Properties

Colourless Powder

Uses

Acyclovir-d4 can be intended for use as an internal standard for the quantification of Acyclovir by GC- or LC-mass spectrometry.

Uses

Acyclovir-d4can be ued as orally active acyclic labelled nucleoside with inhibitory activity towards several herpes viruses.

References

[1] BALFOUR H H. Management of cytomegalovirus disease with antiviral drugs.[J]. Reviews of infectious diseases, 1990, 12 Suppl 7: S849-60. DOI: 10.1093/clinids/12.supplement_7.s849
[2] BEAN B. Antiviral therapy: current concepts and practices.[J]. Clinical Microbiology Reviews, 1992, 5 2: 146-182. DOI: 10.1128/cmr.5.2.146
[3] R J ASHTON. Antiviral activity of famciclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16.[J]. Journal of Antimicrobial Chemotherapy, 1994, 34 2: 287-290. DOI: 10.1093/jac/34.2.287

ACYCLOVIR-D4(1185179-33-2)Related Product Information

• Valaciclovir
• MONO-DESACETYL FAMCICLOVIR
• Famciclovir Related Compound A (20 mg) (2-[2-(2-Amino-9H-purin-9-yl)ethyl]propane-1,3-diol hydrochloride)
• L-Valine 2-Hydroxyethyl Ester 4-Methylbenzenesulfonate
• N-ForMyl Valacyclovir
• acyclovir triphosphate
• FAMCICLOVIR-D4
• 9-(2'-ACETOXYETHOXYMETHYL)-GUANINE
• N-Methyl Valganciclovir Hydrochloride
• N-t-Boc-valacyclovir
• 2-[2-(2-AMINO-9H-PURIN-9-YL)ETHYL]-1,3-PROPANEDIOL
• Valganciclovir
• Famciclovir
• Valganciclovir hydrochloride
• Valaciclovir EP Impurity H
• Acyclovir IMpurity C
• Guanine
• 9-(2-Hydroxyethyl)guanine