Valganciclovir
Valganciclovir Basic information
- Product Name:
- Valganciclovir
- Synonyms:
-
- valganciclovir
- Valganciclovir & Valganciclovir Hydrochloride
- Valganciclovir-d8
- (2S)-2-((2-AMino-6-oxo-1H-purin-9(6H)-yl)Methoxy)-3-hydroxypropyl 2-aMino-3-Methylbutanoate
- 5-amino-3-[1-(hydroxymethyl)-2-(l-valyloxy)ethoxymethyl]-6,7- dihydro-3h-imidazo[4,5-d]pyrimidin-7-one
- Valgancyclovir
- Valganciclovir-d5 HCl (Mixture of diastetroMers)
- Valganciclovir-d8 (Mixture of Diastereomers)
- CAS:
- 175865-60-8
- MF:
- C14H22N6O5
- MW:
- 354.36
- EINECS:
- 1312995-182-4
- Product Categories:
-
- API
- Mol File:
- 175865-60-8.mol
Valganciclovir Chemical Properties
- Density
- 1.59±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 9.32±0.20(Predicted)
- BCS Class
- 3
- CAS DataBase Reference
- 175865-60-8(CAS DataBase Reference)
Safety Information
- Hazardous Substances Data
- 175865-60-8(Hazardous Substances Data)
Valganciclovir Usage And Synthesis
Uses
Antiviral.
Uses
Valganciclovir-d8, is the labeled analogue of Valganciclovir (V092000), a pro-drug of Ganciclovir, used in treatment of retro-virus.
Definition
ChEBI: The L-valinyl ester of ganciclovir, into which it is rapidly converted by intestinal and hepatic esterases. It is a synthetic analogue of 2'-deoxyguanosine.
Indications
Valganciclovir (Valcyte) is the L-valyl ester prodrug of ganciclovir.
brand name
Valcyte (Roche).
Clinical Use
Oral valganciclovir is comparable to intravenous ganciclovir for the treatment and suppression of CMV retinitis in AIDS patients.
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: increased risk of convulsions with
imipenem-cilastatin.
Antivirals: possibly increased didanosine
concentration; profound myelosuppression with
zidovudine - avoid if possible.
Mycophenolate: possibly increased concentrations of
both mycophenolic acid and ganciclovir.
Increased risk of myelosuppression with other
myelosuppressive drugs.
Metabolism
Valganciclovir is well absorbed from the gastrointestinal tract and rapidly and extensively metabolised in the intestinal wall and liver to ganciclovir. Valganciclovir is eliminated in the urine as unchanged ganciclovir, mainly by glomerular filtration and also active tubular secretion.
ValganciclovirSupplier
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Valganciclovir(175865-60-8)Related Product Information
- Ganciclovir sodium
- Ganciclovir
- Glycine
- Guaiacol
- 4-Methoxyphenol
- 6-Aminocaproic acid
- ALTRENOGEST
- 3-Aminophenol
- Anisole
- (Trifluoromethoxy)benzene
- Tris(hydroxymethyl)aminomethane
- 4-Aminobutyric acid
- Valganciclovir-d8
- Valacyclovir hydrochloride
- Valaciclovir
- Ganciclovir Mono-O-acetate
- VALGANCICLOVIR HYDROCHLORIDE,VALGANCICLOVIR HCL
- r-Amino Butryric Acid