uperolein
uperolein Basic information
- Product Name:
- uperolein
- Synonyms:
-
- 2-(L-Proline)-6-(L-alanine)physalemin
- 5-Oxo-L-Pro-L-Pro-L-Asp-L-Pro-L-Asn-L-Ala-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2
- L-Methioninamide, 5-oxo-L-prolyl-L-prolyl-L-α-aspartyl-L-prolyl-L-asparaginyl-L-alanyl-L-phenylalanyl-L-tyrosylglycyl-L-leucyl-
- CAS:
- 55601-63-3
- MF:
- C57H79N13O16S
- MW:
- 1234.38
- Mol File:
- 55601-63-3.mol
uperolein Usage And Synthesis
Uses
Uperolein is a physalaemin-like endecapeptide, produced in the skin of Uperoleia rugosa and Uperoleia marmorata. Uperolein has a spasmodic effect on both the gastrointestinal tract and longitudinal muscles[1][2][3].
in vivo
Uperolein (0.1 μg/kg and 5 μg/kg; i.v.; single dose) exhibits stimulation activity on the stomach of the anesthetized rat, displays a noticeable spasmogenic activity on the whole stomach from the fundus to the pylorus[3].
References
[1] Poulter L, et al. Levitide, a neurohormone-like peptide from the skin of Xenopus laevis. Peptide and peptide precursor cDNA sequences. J Biol Chem. 1988 Mar 5;263(7):3279-83. PMID:2830279
[2] Anastasi A, et al. Structure of uperolein, a physalaemin-like endecapeptide occurring in the skin of Uperoleia rugosa and Uperoleia marmorata. Experientia. 1975 Apr 15;31(4):394-5. DOI:10.1007/BF02026336
[3] Zappia L, et al. Effects of natural analogues of substance P on the motility of human gastrointestinal tract in vitro. J Pharm Pharmacol. 1978 Sep;30(9):593-4. DOI:10.1111/j.2042-7158.1978.tb13335.x
[4] Bertaccini G, et al. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):163-6. DOI:10.1007/BF00508624