2-benzamido-3-methylbutanoic acid Chemical Properties

Melting point:

132°C

Boiling point:

451.8±28.0 °C(Predicted)

Density 

1.157±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

almost transparency in Methanol

form 

powder to crystal

pka

3.79±0.10(Predicted)

color 

White to Almost white

LogP

1.536 (est)

CAS DataBase Reference

2901-80-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

2924.21.4500

HazardClass 

IRRITANT

MSDS

• Language:English Provider:SigmaAldrich

2-benzamido-3-methylbutanoic acid Usage And Synthesis

Uses

Benzoyl-DL-Valine is a valine derivative[1].

Synthesis

Step A: Synthesis of N-benzoyl-DL-valine 1. 0.1 mole (11.7 g) of DL-valine was dissolved in 50 mL of deionized water. 2. 0.25 moles of aqueous sodium hydroxide was added to the above solution. 3. The reaction mixture was heated to 30 °C and 0.15 mol (17.5 mL) of benzoyl chloride was added slowly and dropwise with stirring. 4. Upon completion of the reaction, the aqueous phase is extracted with ether to remove unreacted benzoyl chloride and other organic impurities. 5. The aqueous phase is acidified to pH 2-3 to induce precipitation of N-benzoyl-DL-valine crystals. 6. 6. The crystals are collected by filtration and washed with a small amount of cold water. 7. 7. N-benzoyl-DL-valine was obtained after drying and the melting point was determined to be 125° C. The yield was about 95%.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

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