M 8218 Chemical Properties

Boiling point:

461.0±35.0 °C(Predicted)

Density 

1.14±0.1 g/cm3(Predicted)

pka

13?+-.0.29(Predicted)

M 8218 Usage And Synthesis

Uses

Penehyclidine, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1][2].

IC 50

mAChR1; mAChR3; NF-κB

References

[1] Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885. DOI:10.2147/COPD.S295329
[2] Xiao HT, et al. Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors. Drug Des Devel Ther. 2012;6:317-22. DOI:10.2147/DDDT.S36555

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