(R*,S*)-(-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone
(R*,S*)-(-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone Basic information
- Product Name:
- (R*,S*)-(-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone
- Synonyms:
-
- (r*,s*)-(-)-8-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1h)-quinolinone
- PROCATEROL
- 2(1h)-quinolinone,8-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-,(r*,
- 8-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1h)-quinolinone(r*,s
- s*)-(+-)-
- ent-Florfenicol AMine-d3
- (S)-N,N-DiMethyl-3-(1-naphthalenyl-d7-oxy)-3-(2-thienyl)propanaMine
- ANTI-SARS VIRUS SM antibody produced in rabbit
- CAS:
- 72332-33-3
- MF:
- C16H22N2O3
- MW:
- 290.36
- EINECS:
- 276-590-0
- Mol File:
- 72332-33-3.mol
(R*,S*)-(-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone Chemical Properties
- Melting point:
- 107-109°C
- storage temp.
- -20°C
- solubility
- Acetonitrile (Slightly), Chloroform (Slightly), Methanol
- form
- Solid
- color
- White to Off-White
- CAS DataBase Reference
- 72332-33-3(CAS DataBase Reference)
(R*,S*)-(-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone Usage And Synthesis
Description
Like pirbuterol, procaterol exhibits similar broncholytic properties as albuteral, but it has somewhat of a more prolonged action. It is recommended for use as an inhaled drug for treating bronchial asthma.
Chemical Properties
Off-White Solid
Uses
A labelled intermediate of the enantiomer of Florfenicol (F405750), an antibacterial agent.
Definition
ChEBI: 8-hydroxy-5-[1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one is a member of quinolines.
brand name
Pro-Air (Parke-Davis).
Synthesis
Procaterol, 5-[1-hydroxy-2-[(1-methylethyl)amino]butyl]-8-hydroxy-2-(1H) quinolone (23.3.25), is synthesized by acylation of 8-hydroxy-2(1H)-quinolone with 2-bromobutyric acid chloride at the fifth position of the quinoline system, which gives the compound 23.3.23. This undergoes action of isopropylamine, forming an aminoketone 23.3.24, the carbonyl group of which is reduced by sodium borohydride, giving procaterol (23.3.25) .
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