3-hydroxylidocaine Chemical Properties

Melting point:

192-195°C

Boiling point:

390.8±42.0 °C(Predicted)

Density 

1.103±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

10.18±0.23(Predicted)

color 

Light Brown

3-hydroxylidocaine Usage And Synthesis

Description

3’-hydroxy Lidocaine is an active metabolite of lidocaine formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.

Chemical Properties

Light Brown Solid

Uses

A metabolite of Lidocaine (L397800).

Definition

ChEBI: 3-Hydroxylidocaine is an amino acid amide.

References

[1] J S WANG. Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.[J]. Drug Metabolism and Disposition, 2000, 28 8: 959-965.
[2] J?RGEN HERMANSSON. Metabolism of Lidocaine in Human Liver in Vitro[J]. Basic & Clinical Pharmacology & Toxicology, 1980, 47 1: 49-52. DOI: 10.1111/j.1600-0773.1980.tb02024.x

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