N-ARACHIDOYL-D-ERYTHRO-SPHINGOSINE Chemical Properties

Melting point:

89-90°C

Boiling point:

646.97°C (rough estimate)

Density 

0.9431 (rough estimate)

refractive index 

1.5350 (estimate)

storage temp. 

-20°C

solubility 

DMF: 0.15 mg/ml

form 

A crystalline solid

pka

13.54±0.20(Predicted)

color 

White to off-white

Stability:

Stable, but may be heat sensitive - store at -20 C. Incompatible with oxidizing agents.

Safety Information

Safety Statements 

24/25

MSDS

• Language:English Provider:ACROS

N-ARACHIDOYL-D-ERYTHRO-SPHINGOSINE Usage And Synthesis

Description

Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway. Certain forms of ceramide have been shown to mediate cellular responses such as apoptosis, growth arrest, and differentiation in certain cell types. C20 Ceramide is a natural 20:0 ceramide that is abundant in the brain. It is synthesized de novo by ceramide synthases 1 and 2.

Chemical Properties

white powder

Uses

C20 Ceramide (cas# 7344-02-7) is a compound useful in organic synthesis.

Definition

ChEBI: N-icosanoylsphingosine is a N-acylsphingosine in which the ceramide N-acyl group is specified as eicosanoyl. It has a role as a mouse metabolite. It is a N-acylsphingosine and a Cer(d38:1). It is functionally related to an icosanoic acid.

IC 50

Human Endogenous Metabolite

References

[1] COWART L A. Sphingolipids: players in the pathology of metabolic disease.[J]. Trends in Endocrinology and Metabolism, 2009, 20 1: 34-42. DOI: 10.1016/j.tem.2008.09.004
[2] YAEL PEWZNER-JUNG  Anthony H F  Shifra Ben Dor. When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis.[J]. The Journal of Biological Chemistry, 2006, 281 35: 25001-25005. DOI: 10.1074/jbc.r600010200

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