(1R,2R)-B13 Chemical Properties

Boiling point:

636.2±55.0 °C(Predicted)

Density 

1.101±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): .3 mg/ml

form 

A crystalline solid

pka

12.72±0.20(Predicted)

color 

white to beige

optical activity

[α]/D -28 to -34, c =0.1 in chloroform-d

(1R,2R)-B13 Usage And Synthesis

Uses

D-NMAPPD is d-NMAPPD is a potent Acid Ceramidase inhibitor that induces apoptosis..

Biological Activity

D-NMAPPD (B13), a myristoyl-CoA analog, is a cell penetrant inhibitor of N-myristoyltransferases th at suppressed FRS2α (fibroblast growth factor receptor substrate 2) myristoylation. D-NMAPPD inhibits wild-type FGFRs and drug-resistant mutants (FGFRsDRM) oncogenic signaling in cancer cells. D-NMAPPD potently inhibits growth of xenograft tumors in mice. D-NMAPPD is a potent inhibitor of ceramidase th at elevates endogenous ceramide levels and suppress growth of cancer cells.

(1R,2R)-B13(35922-06-6)Related Product Information

• D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
• (1R,2R)-B13