D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Chemical Properties

Melting point:

163-165 °C(lit.)

Boiling point:

352.03°C (rough estimate)

Density 

1.3136 (rough estimate)

refractive index 

-30.5 ° (C=1, 6mol/L HCl)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

Water Solubility 

almost transparency in hot Water

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

10.98±0.45(Predicted)

form 

Powder

color 

Light yellow

optical activity

[α]25/D 30°, c = 1 in 6 M HCl

InChIKey

OCYJXSUPZMNXEN-RKDXNWHRSA-N

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

22-36/37/38-45

Safety Statements 

26-45-53-22

RIDADR 

UN 3259 8/PG 3

WGK Germany 

3

RTECS 

TY3100000

HS Code 

29221990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Usage And Synthesis

Chemical Properties

light yellow powder

Uses

Chloramphenicol base is the parent 4-nitrophenylpropylamine formed by the hydrolysis of the dichloroacetamide of chloramphenicol and is a degradation product commonly encountered with commercial production of chloramphenicol. Chloramphenicol base has no antibiotic activity but has played an integral role in the synthesis and SAR of new generation antibiotics, notably thiamphenicol and experimental analogues, bromamphenicol and methamphenicol.

Uses

(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol may be used in the preparation of (1R,2R)-(-)-2-dimethylamino-1-(4-nitrophenyl)-1,3-propanediol via N,N-dimethylation. It may also be used as a starting material to synthesize (1R,2R)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propylisothioeyanate [(R,R)-DANI].

Uses

D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is an impurity of Chloramphenicol (C325030), a broad spectrum antibiotic agent obtained from cultures of the soil bacterium Streptomyces venezuel ae.

Definition

ChEBI: A diol that is propane 1,3-diol bearing additional amino and 4-nitrophenyl substituents at positions 2 and 1 respectively.

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL(716-61-0)Related Product Information

• Chloramphenicol palmitate
• D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
• Chloramphenicol sodium succinate
• Eusynthomycin
• Chloramphenicol
• (1S,2S)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol
• 2-Amino-1,3-propanediol
• Nitrophenol
• 2-Amino-1-(4-nitrophenyl)-1,3-propanediol
• CHLORAMPHENICOL 1-O-BETA-D-GALACTOPYRANOSIDE
• (1R,2R)-B13
• BROMAMPHENICOL
• CHLORAMPHENICOL (D5)
• CHLORAMPHENICOL-ALCOHOL
• L-(+)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
• BOC-(1R,2R)-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
• FMOC-(1R,2R)-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
• D-THREO-[DICHLOROACETYL-1-14C]-CHLORAMPHENICOL