Propiophenone Chemical Properties

Melting point:

17-19 °C(lit.)

Boiling point:

218 °C(lit.)

Density 

1.009 g/mL at 25 °C(lit.)

vapor pressure 

1 mm Hg ( 50 °C)

refractive index 

n20/D 1.526(lit.)

FEMA 

3469 | PROPIOPHENONE

Flash point:

190 °F

storage temp. 

Store below +30°C.

solubility 

Insoluble in water, soluble in alcohol and oils

form 

Liquid

color 

Clear colorless to light yellow

Odor

at 10.00 % in dipropylene glycol. hawthorn lilac floral aromatic cherry herbal

Odor Type

floral

Water Solubility 

INSOLUBLE

JECFA Number

824

Merck 

14,7830

BRN 

606215

Dielectric constant

15.5

Stability:

Stable. Incompatible with strong oxidizing agents, strong bases.

InChIKey

KRIOVPPHQSLHCZ-UHFFFAOYSA-N

LogP

2.71

CAS DataBase Reference

93-55-0(CAS DataBase Reference)

NIST Chemistry Reference

1-Propanone, 1-phenyl-(93-55-0)

EPA Substance Registry System

Propiophenone (93-55-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

2

RTECS 

UG7175000

TSCA 

Yes

HS Code 

2914 39 00

Hazardous Substances Data

93-55-0(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 4490 mg/kg LD50 dermal Rabbit 4490 mg/kg

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Propiophenone Usage And Synthesis

Description

Propiophenone belongs to the family of acetophenones, which is present in some certain cheese, coffee and coffee products, tea and roasted nuts with sweet-smelling odor. It is wisely used as an intermediate in the preparation of other organic compounds, such as synthetic aryl alkenes, like cinnamic acids. It is also a useful intermediate for pharmaceuticals production, such as ephedrine, propiophenone derivatives (cathinone and methcathinone), and especially for the preparation of nervous system drugs (anxiolytic and hypnotic drugs). Besides, due to its naturally pleasant flowery odor, propiophenone can be used as a component in some perfumes.

References

https://en.wikipedia.org/wiki/Propiophenone
https://pubchem.ncbi.nlm.nih.gov/compound/7148#section=Top
http://www.chemicalland21.com/industrialchem/organic/PROPIOPHENONE.htm
https://www.alfa.com/en/catalog/A15140/

Chemical Properties

Propiophenone has a strong, flowery odor. 1-Phenyl-1-propanone is a colorless liquid with a flowery odor, insoluble in water, readily soluble in organic solvents. Typical reactions can be carried out at the methylene group, the carbonyl group, and at the aromatic nucleus.

Occurrence

Reported found in coffee, roasted filberts, roasted peanuts and roasted green tea. Also reported found in Camembert cheese, black tea, roasted macadamia nut, tamarind, dried bonito, cherimoya and sapodilla fruit.

Uses

1-Phenyl-1-propanone is used mainly as an intermediate for pharmaceuticals such as DPropoxyphen, phenylpropanolamine, and Phenmetrazine.

Uses

Propiophenone is an aryl ketone used in the preparation of pharmaceutical and organic compounds. Propiophenone is used in perfumes as well as in the preparation of neurochemical compounds such as ephe drines.

Uses

In perfumery; in the synthesis of ephedrine and related Compounds.

Definition

ChEBI: Propiophenone is an aromatic ketone in which the two substituents on the carbonyl C atom are phenyl and ethyl. It has a role as a fragrance.

Production Methods

Propiophenone is produced by the Friedel–Crafts acylation of benzene with propionic acid chloride in the presence of aluminum chloride. It may also be produced by the reaction of benzoic acid and propionic acid using a calcium acetate– aluminum oxide catalyst.

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 2430, 1995 DOI: 10.1021/jo00113a024
Tetrahedron Letters, 30, p. 4819, 1989 DOI: 10.1016/S0040-4039(01)80517-7

Flammability and Explosibility

Not classified

Safety Profile

Poison by intraperitoneal route. Moderately toxic by subcutaneous route. Mildly toxic by ingestion and skin contact. A skin and eye irritant. A flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Propiophenone(93-55-0)Related Product Information

• PHENYL VALERATE
• Citric acid monohydrate
• 3-Pentanone
• Phenylhydrazine
• Ethylparaben
• 4'-Chloropropiophenone
• Ethanol
• Ethyl acetate
• Ethyl acrylate
• 3-(2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• 2-BROMO-2-PHENYLACETOPHENONE
• 4'-Fluoropropiophenone
• 4'-BROMOVALEROPHENONE
• METHYL 4-FLUOROBENZOYLACETATE
• Propiophenone
• 3'-Chloropropiophenone
• 4'-Hydroxypropiophenone
• Diethyl ether