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4'-Hydroxypropiophenone

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4'-Hydroxypropiophenone Basic information

Product Name:
4'-Hydroxypropiophenone
Synonyms:
  • PARA-ETHYLKETOPHENOL
  • PARA-PROPIONYLPHENOL
  • 4-HYDROXYPROPIOPHENONE / PAROXYPROPIONE
  • 1-(4-hydroxyphenyl)propan-1-one
  • 4''-HYDROXYPROPRIOPHENONE
  • 4′-Hydroxypropiophen
  • P-acetone
  • 4'-Hydroxypropiophenone, 97+%
CAS:
70-70-2
MF:
C9H10O2
MW:
150.17
EINECS:
200-743-2
Product Categories:
  • C9
  • Carbonyl Compounds
  • Acetophenone Series
  • Aromatic Propiophenones (substituted)
  • Ketones
  • PROFENONE
  • Building Blocks
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks
Mol File:
70-70-2.mol
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4'-Hydroxypropiophenone Chemical Properties

Melting point:
36-38 °C(lit.)
Boiling point:
152-154 °C26 mm Hg(lit.)
Density 
1.09 g/cm3 (20℃)
FEMA 
2005 | ACETANISOLE
refractive index 
1.5360 (estimate)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
methanol: 0.1 g/mL, clear
pka
8.87±0.26(Predicted)
Water Solubility 
0.34 g/l (15 ºC)
Merck 
14,7044
BRN 
907511
CAS DataBase Reference
70-70-2(CAS DataBase Reference)
NIST Chemistry Reference
1-Propanone, 1-(4-hydroxyphenyl)-(70-70-2)
EPA Substance Registry System
1-Propanone, 1-(4-hydroxyphenyl)- (70-70-2)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38
Safety Statements 
37-24/25-36-26
WGK Germany 
3
RTECS 
UH1925000
TSCA 
Yes
HS Code 
29145000
Toxicity
LD50 orally in Rabbit: 11800 mg/kg

MSDS

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4'-Hydroxypropiophenone Usage And Synthesis

Chemical Properties

white powder

Uses

gonadotropic hormone inhibitor

Uses

p-Hydroxypropiophenone is a 4-hydroxyphenyl ketone used in the preparation of potential antitumor agents. p-Hydroxypropiophenone is a lignin degrradation product.

Uses

Intermediates of Liquid Crystals

Preparation

Preparation by Fries rearrangement of phenyl propionate
with aluminium chloride in refluxing carbon disulfide ? then at 130–150° for 2–3 h after solvent elimination (45–50%)
with aluminium chloride in nitrobenzene at 50° for 18 h (72%) or at ? 20° for 48 h (60%)
with aluminium chloride in nitromethane at 20° for 7–8 days (80%)
with aluminium chloride in chlorobenzene using microwave irradiation for ? 3 min at 106° (62%)
with aluminium chloride in ethylene dichloride at 95° for 5 h or in heptane at ? 80–90° for 7 h (36%), in benzene or in tetrachloroethane at 80°; with aluminium chloride in the presence of propionyl chloride at 50–60° for ? 6 h (49%)
with aluminium chloride without solvent at 50° for 10 h
with titanium tetrachloride in nitromethane at 20° for 7 days (56%) or ? without solvent at 50° for 10 h (39%)
with polyphosphoric acid at 100° (61%)
with boron trifluoride at 50° for 3 h (46%)
with stannic chloride at 50° for 3 h (10%).

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 2491, 1965 DOI: 10.1021/jo01018a528

Safety Profile

Poison by intraperitoneal, subcutaneous, and parenteral routes. An experimental teratogen. Other experimental reproductive effects. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Purification Methods

4'-Hydroxypropiophenone [70-70-2] M 150.2, m 149o, b 140-145o/0.5mm, 8.05. Crystallise the phenone from H2O (m 149.8-150.2o) or EtOH (m 147o). The benzoyl derivative has m 117o, and the semicarbazone has m 183o (EtOH). [Beilstein 8 H 102, 8 II 104, 8 III 379.]

4'-Hydroxypropiophenone Preparation Products And Raw materials

Raw materials

4'-HydroxypropiophenoneSupplier

J & K SCIENTIFIC LTD.
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INTATRADE GmbH
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+49 3493/605464
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Chembest Research Laboratories Limited
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Alfa Aesar
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