4-Hydroxybenzyl alcohol Chemical Properties

Melting point:

114-122 °C(lit.)

Boiling point:

251-253°C

Density 

1.1006 (rough estimate)

refractive index 

1.5035 (estimate)

FEMA 

3987 | 4-HYDROXYBENZYL ALCOHOL

Flash point:

251-253°C

storage temp. 

Store below +30°C.

solubility 

6.7g/l soluble

form 

Crystalline Powder

pka

pK1:9.82 (25°C)

color 

Pink to beige

Odor

at 100.00 %. fruity bitter almond sweet coconut

Odor Type

fruity

Water Solubility 

Soluble in water (6.7 mg/ml at 20°C), dioxane (100 mg/ml), 1N NaOH (50 mg/ml), DMSO, and methanol.

Sensitive 

Light Sensitive/Air Sensitive

JECFA Number

955

BRN 

1858967

InChIKey

BVJSUAQZOZWCKN-UHFFFAOYSA-N

LogP

0.21

CAS DataBase Reference

623-05-2(CAS DataBase Reference)

NIST Chemistry Reference

Benzenemethanol, 4-hydroxy-(623-05-2)

EPA Substance Registry System

4-Hydroxybenzenemethanol (623-05-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36-36/37/38

Safety Statements 

26-24/25-36

WGK Germany 

3

RTECS 

DA4796800

F 

8-9-23

Hazard Note 

Irritant/Keep Cold/Air Sensitive/Light Sensitive

HS Code 

29072900

MSDS

• Language:English Provider:4-hydroxybenzenemethanol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Hydroxybenzyl alcohol Usage And Synthesis

Chemical Properties

Pink to beige crystalline powder

Chemical Properties

4-Hydroxybenzyl alcohol is a white crystalline powder with slightly fruity-sweet coconut odor

Occurrence

Reportedly found in vanilla, Bourbon (Vanilla plantifolia Andrew

Uses

4-Hydroxybenzyl alcohol is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Preparation

Prepared from p-cresol by using the microorganism, Pseudomonas putida.

Definition

ChEBI: P-hydroxybenzyl alcohol is a member of the class of benzyl alcohols that is benzyl alcohol substituted by a hydroxy group at position 4. It has been isolated from Arcangelisia gusanlung. It has a role as a plant metabolite. It is a member of phenols and a member of benzyl alcohols.

General Description

4-Hydroxybenzyl alcohol (HBA) is a phenolic compound found in Gastrodia elata. It is as an antioxidant and anti-asthmatic agent.

Flammability and Explosibility

Not classified

Contact allergens

Methylol phenols are sensitizers contained in resins based on phenol and formaldehyde of the resol type. Cross-reactivity is possible with other phenol derivative molecules.

IC 50

IC50 >0.2 mM (human); ALDH5A1: IC50 >1 mM (human); ABAT: IC50 >1 mM (human); Tyrosinase: IC50 >1 mM (Agaricus bisporus)

Purification Methods

Crystallise the alcohol from H2O, *C6H6 (m 124o), *C6H6/EtOH or ClCH2CH2Cl (m 122o). [Beilstein 6 III 4546, 6 IV 5909.]

4-Hydroxybenzyl alcohol(623-05-2)Related Product Information

• 4-Hydroxy-D-(-)-2-phenylglycine
• Benzyl alcohol
• Triphenylmethanol
• 3,5-Dihydroxybenzyl alcohol
• Benzhydrol
• Ethyl acetate
• Ethylparaben
• 4-Cyanobenzoic acid
• 4-Methoxyphenol
• 4-Hydroxybenzoic acid
• 4-Hydroxybenzaldehyde
• 3-(4-Hydroxyphenyl)propionic acid
• Methyl 4-hydroxyphenylacetate
• Bisoprolol Impurity 17
• Bisoprolol Impurity 11
• Bisoprolol Impurity 16
• Acetamide, N-[2-hydroxy-3-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]propyl]-N-(1-methylethyl)-
• 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenol hydrochloride