D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL

Product Name: D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
CAS No.: 716-61-0
Chemical Name: D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
Synonyms: (1R,2R)-2-AMINO-1-(4-NITROPHENYL)PROPANE-1,3-DIOL;ChloromycinbaseL-base;levoamine;Chloromycin base;L-BASE (AMINODIOL);chloramphenicolbase;D(-)Threo-1-(4-nitro;Chloramphenicol impurity D;Chloramphenicol Impurity 1;Chloramphenicol Impurity A
CBNumber: CB6452870
Molecular Formula: C9H12N2O4
Formula Weight: 212.2
MOL File: 716-61-0.mol

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D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Property

Melting point:: 163-165 °C(lit.)
Boiling point:: 352.03°C (rough estimate)
Density: 1.3136 (rough estimate)
refractive index: -30.5 ° (C=1, 6mol/L HCl)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Water Solubility: almost transparency in hot Water
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 10.98±0.45(Predicted)
form: Powder
color: Light yellow
optical activity: [α]25/D 30°, c = 1 in 6 M HCl
InChIKey: OCYJXSUPZMNXEN-RKDXNWHRSA-N

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Safety

Hazard Codes: Xn,T
Risk Statements: 22-36/37/38-45
Safety Statements: 26-45-53-22
RIDADR: UN 3259 8/PG 3
WGK Germany: 3
RTECS: TY3100000
HS Code: 29221990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A70704
Product name: (1R,2R)-(?)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
Purity: 99%
Packaging: 10g
Price: $107
Updated: 2024/03/01

Sigma-Aldrich

Product number: A70704
Product name: (1R,2R)-(?)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
Purity: 99%
Packaging: 25g
Price: $146
Updated: 2024/03/01

TCI Chemical

Product number: A1017
Product name: D-(-)-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
Purity: >98.0%(T)
Packaging: 25g
Price: $79
Updated: 2024/03/01

TCI Chemical

Product number: A1017
Product name: D-(-)-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
Purity: >98.0%(T)
Packaging: 500g
Price: $689
Updated: 2024/03/01

TRC

Product number: A622680
Product name: D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
Packaging: 50g
Price: $240
Updated: 2021/12/16

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D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Chemical Properties,Usage,Production

Chemical Properties

light yellow powder

Uses

Chloramphenicol base is the parent 4-nitrophenylpropylamine formed by the hydrolysis of the dichloroacetamide of chloramphenicol and is a degradation product commonly encountered with commercial production of chloramphenicol. Chloramphenicol base has no antibiotic activity but has played an integral role in the synthesis and SAR of new generation antibiotics, notably thiamphenicol and experimental analogues, bromamphenicol and methamphenicol.

Uses

(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol may be used in the preparation of (1R,2R)-(-)-2-dimethylamino-1-(4-nitrophenyl)-1,3-propanediol via N,N-dimethylation. It may also be used as a starting material to synthesize (1R,2R)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propylisothioeyanate [(R,R)-DANI].

Uses

D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is an impurity of Chloramphenicol (C325030), a broad spectrum antibiotic agent obtained from cultures of the soil bacterium Streptomyces venezuel ae.

Definition

ChEBI: A diol that is propane 1,3-diol bearing additional amino and 4-nitrophenyl substituents at positions 2 and 1 respectively.

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Preparation Products And Raw materials

Raw materials

Propiophenone

Preparation Products

Potassium heptadecafluoro-1-octanesulfonate

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D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Suppliers

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View Lastest Price from D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: ChloromycinbaseL-base 716-61-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Guangzhou Sunton Biotechnology Co., Ltd.

Product: D(-)Threo-1-(4-nitrophenyl)-2-amino-1,3-propanediol 716-61-0
Price: US $48.00-40.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200tons
Release date: 2021-03-30

Henan Aochuang Chemical Co.,Ltd.

Product: D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL 716-61-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

716-61-0, D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOLRelated Search:

Chloramphenicol palmitate D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Chloramphenicol sodium succinate Eusynthomycin Chloramphenicol (1S,2S)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol 2-Amino-1,3-propanediol Nitrophenol 2-Amino-1-(4-nitrophenyl)-1,3-propanediol CHLORAMPHENICOL 1-O-BETA-D-GALACTOPYRANOSIDE (1R,2R)-B13 BROMAMPHENICOL CHLORAMPHENICOL (D5) CHLORAMPHENICOL-ALCOHOL L-(+)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL BOC-(1R,2R)-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL FMOC-(1R,2R)-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL D-THREO-[DICHLOROACETYL-1-14C]-CHLORAMPHENICOL

ChloromycinbaseL-base

D-(-)-THREO-2-AMINO-1-(4-NITRO

(1R,2R)-1-(4-Nitrophenyl)-2-aminopropane-1,3-diol

[1R,2R,(-)]-2-Amino-1-(p-nitrophenyl)-1,3-propanediol

(1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol,96%

(1R,2R)-()-2-Amino-1-(4-nitrophenyl)-1,3-propanediol,D-()-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol, Chloramphenicol base

(1R,2R)-2-AMino-1-(4-nitrophenyl)propane-1,3-diol, 96% 5GR

(1R,2R)-(-)-2-AMino-1-(4-nitrophenyl)-1,3-propanediol 99%

(1R,2R)-(-)-2-AMino-1-(4-nitrophenyl)-1,3-propanediol, 96%, 96%

(1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol hydrochloride

L-BASE (AMINODIOL)

<small>D</small>-(-)-<i>threo</i>-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol≥ 99% (by Assay)

d-threo-(-)-2-amino-1-(p-nitrophenyl)-1,3-propanediol

levoamine

Chloromycin base

2-amino-1-(p-nitrophenyl)-3-propanediod-threo-(-)-

chloramphenicolbase

Chloramphenicol base, D-(-)-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol

(1R,2R)-(-)-2-Amino-1-(4-nitrophenyL

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL

D(-)THREO-1-(4-NITRO-PHENYL)-2-AMINO-1,3-PROPANEDIOL

CHLORAMPHENICOL-WATER SOLUBLE

(1R,2R)-2-AMINO-1-(4-NITROPHENOL)PROPANE-1,3-DIOL

(1R,2R)-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL

(1R,2R)-2-AMINO-1-(4-NITROPHENYL)PROPANE-1,3-DIOL

CHLORAMPHENICOL BASE CRYSTALLINE

(1R,2R)-(-)-2-AMINO-1-ITROPHENYL)-1,3-PR OPANEDIOL,99%

D(-)Threo-1-(4-nitro-phenyl)-2

1,3-Propanediol, 2-amino-1-(4-nitrophenyl)-, (1R,2R)-

D-THREO-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANE

(1R,2R)-(-)-2-AMINO-1-NITROPHENYL)-1,3-PROPANEDIOL

D-(-)threo-2-amino-1-(p-nitrophenyl)propane-1,3-diol

(R,R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol

(1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol nitrate

Chloramphenicol impurity D

(D)-(-)-threo-2-Amino-1-(4-nitrophe

Chloramphenicol Impurity 1 (D-(-)-Threo-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol)

D-(-)-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol &gt

Chloramphenicol Impurity 1

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL USP/EP/BP

D(-)Threo-1-(4-nitro

(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-aminium

D-(-)-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol/D-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol

Chloramphenicol Impurity A

Aminonitrophenolpropanediol

D-(-)-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol, ≥ 98.0%

2-[(1R,2R)-2-amino-1,3-dihydroxypropyl]benzoic acid

716-61-0

C9H12O4N2

C9H13N2O4

HOCH2CHNH2CHC6H4NO2OH

AMINE

Amino Alcohols

Asymmetric Synthesis

Organic Building Blocks

Optical Resolution

Chiral Building Blocks