ChemicalBook > CAS DataBase List > D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL

Product Name
D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
CAS No.
716-61-0
Chemical Name
D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
Synonyms
(1R,2R)-2-AMINO-1-(4-NITROPHENYL)PROPANE-1,3-DIOL;ChloromycinbaseL-base;levoamine;Chloromycin base;L-BASE (AMINODIOL);chloramphenicolbase;D(-)Threo-1-(4-nitro;Chloramphenicol impurity D;Chloramphenicol Impurity 1;Chloramphenicol Impurity A
CBNumber
CB6452870
Molecular Formula
C9H12N2O4
Formula Weight
212.2
MOL File
716-61-0.mol
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D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Property

Melting point:
163-165 °C(lit.)
Boiling point:
352.03°C (rough estimate)
Density 
1.3136 (rough estimate)
refractive index 
-30.5 ° (C=1, 6mol/L HCl)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Water Solubility 
almost transparency in hot Water
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
10.98±0.45(Predicted)
form 
Powder
color 
Light yellow
optical activity
[α]25/D 30°, c = 1 in 6 M HCl
InChIKey
OCYJXSUPZMNXEN-RKDXNWHRSA-N
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Safety

Hazard Codes 
Xn,T
Risk Statements 
22-36/37/38-45
Safety Statements 
26-45-53-22
RIDADR 
UN 3259 8/PG 3
WGK Germany 
3
RTECS 
TY3100000
HS Code 
29221990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A70704
Product name
(1R,2R)-(?)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
Purity
99%
Packaging
10g
Price
$107
Updated
2024/03/01
Sigma-Aldrich
Product number
A70704
Product name
(1R,2R)-(?)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
Purity
99%
Packaging
25g
Price
$146
Updated
2024/03/01
TCI Chemical
Product number
A1017
Product name
D-(-)-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
Purity
>98.0%(T)
Packaging
25g
Price
$79
Updated
2024/03/01
TCI Chemical
Product number
A1017
Product name
D-(-)-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
Purity
>98.0%(T)
Packaging
500g
Price
$689
Updated
2024/03/01
TRC
Product number
A622680
Product name
D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
Packaging
50g
Price
$240
Updated
2021/12/16
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D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Chemical Properties,Usage,Production

Chemical Properties

light yellow powder

Uses

Chloramphenicol base is the parent 4-nitrophenylpropylamine formed by the hydrolysis of the dichloroacetamide of chloramphenicol and is a degradation product commonly encountered with commercial production of chloramphenicol. Chloramphenicol base has no antibiotic activity but has played an integral role in the synthesis and SAR of new generation antibiotics, notably thiamphenicol and experimental analogues, bromamphenicol and methamphenicol.

Uses

(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol may be used in the preparation of (1R,2R)-(-)-2-dimethylamino-1-(4-nitrophenyl)-1,3-propanediol via N,N-dimethylation. It may also be used as a starting material to synthesize (1R,2R)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propylisothioeyanate [(R,R)-DANI].

Uses

D-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol is an impurity of Chloramphenicol (C325030), a broad spectrum antibiotic agent obtained from cultures of the soil bacterium Streptomyces venezuel ae.

Definition

ChEBI: A diol that is propane 1,3-diol bearing additional amino and 4-nitrophenyl substituents at positions 2 and 1 respectively.

D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Preparation Products And Raw materials

Raw materials

Propiophenone

Preparation Products

Potassium heptadecafluoro-1-octanesulfonate
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D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Suppliers

Americas 1 Belgium 1 Canada 1 China 171 Europe 4 Germany 3 India 7 Japan 2 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 10 United States 23 Global 226
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View Lastest Price from D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL manufacturers

Hebei Duling International Trade Co. LTD
Product
D(-)Threo-1-(4-nitrophenyl)-2-amino-1,3-propanediol 716-61-0
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000tons
Release date
2022-10-13
Hebei Yanxi Chemical Co., Ltd.
Product
ChloromycinbaseL-base 716-61-0
Price
US $10.00-3.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
15 tons
Release date
2023-09-27
Hebei Guanlang Biotechnology Co., Ltd.
Product
ChloromycinbaseL-base 716-61-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2022-10-09

716-61-0, D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOLRelated Search:

Chloramphenicol palmitate D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL Chloramphenicol sodium succinate Eusynthomycin Chloramphenicol (1S,2S)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol 2-Amino-1,3-propanediol Nitrophenol 2-Amino-1-(4-nitrophenyl)-1,3-propanediol CHLORAMPHENICOL 1-O-BETA-D-GALACTOPYRANOSIDE (1R,2R)-B13 BROMAMPHENICOL CHLORAMPHENICOL (D5) CHLORAMPHENICOL-ALCOHOL L-(+)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL BOC-(1R,2R)-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL FMOC-(1R,2R)-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL D-THREO-[DICHLOROACETYL-1-14C]-CHLORAMPHENICOL

  • ChloromycinbaseL-base
  • D-(-)-THREO-2-AMINO-1-(4-NITRO
  • (1R,2R)-1-(4-Nitrophenyl)-2-aminopropane-1,3-diol
  • [1R,2R,(-)]-2-Amino-1-(p-nitrophenyl)-1,3-propanediol
  • (1R,2R)-2-Amino-1-(4-nitrophenyl)propane-1,3-diol,96%
  • (1R,2R)-()-2-Amino-1-(4-nitrophenyl)-1,3-propanediol,D-()-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol, Chloramphenicol base
  • (1R,2R)-2-AMino-1-(4-nitrophenyl)propane-1,3-diol, 96% 5GR
  • (1R,2R)-(-)-2-AMino-1-(4-nitrophenyl)-1,3-propanediol 99%
  • (1R,2R)-(-)-2-AMino-1-(4-nitrophenyl)-1,3-propanediol, 96%, 96%
  • (1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol hydrochloride
  • L-BASE (AMINODIOL)
  • <small>D</small>-(-)-<i>threo</i>-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
  • (1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol≥ 99% (by Assay)
  • d-threo-(-)-2-amino-1-(p-nitrophenyl)-1,3-propanediol
  • levoamine
  • Chloromycin base
  • 2-amino-1-(p-nitrophenyl)-3-propanediod-threo-(-)-
  • chloramphenicolbase
  • Chloramphenicol base, D-(-)-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol
  • (1R,2R)-(-)-2-Amino-1-(4-nitrophenyL
  • D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
  • D(-)THREO-1-(4-NITRO-PHENYL)-2-AMINO-1,3-PROPANEDIOL
  • CHLORAMPHENICOL-WATER SOLUBLE
  • (1R,2R)-2-AMINO-1-(4-NITROPHENOL)PROPANE-1,3-DIOL
  • (1R,2R)-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
  • (1R,2R)-2-AMINO-1-(4-NITROPHENYL)PROPANE-1,3-DIOL
  • CHLORAMPHENICOL BASE CRYSTALLINE
  • (1R,2R)-(-)-2-AMINO-1-ITROPHENYL)-1,3-PR OPANEDIOL,99%
  • D(-)Threo-1-(4-nitro-phenyl)-2
  • 1,3-Propanediol, 2-amino-1-(4-nitrophenyl)-, (1R,2R)-
  • D-THREO-(-)-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANE
  • (1R,2R)-(-)-2-AMINO-1-NITROPHENYL)-1,3-PROPANEDIOL
  • D-(-)threo-2-amino-1-(p-nitrophenyl)propane-1,3-diol
  • (R,R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol
  • (1R,2R)-2-amino-1-(4-nitrophenyl)propane-1,3-diol nitrate
  • Chloramphenicol impurity D
  • (D)-(-)-threo-2-Amino-1-(4-nitrophe
  • Chloramphenicol Impurity 1 (D-(-)-Threo-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol)
  • D-(-)-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol &gt
  • Chloramphenicol Impurity 1
  • D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL USP/EP/BP
  • D(-)Threo-1-(4-nitro
  • (1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-aminium
  • D-(-)-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol/D-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol
  • Chloramphenicol Impurity A
  • Aminonitrophenolpropanediol
  • D-(-)-threo-2-Amino-1-(4-nitrophenyl)-1,3-propanediol, ≥ 98.0%
  • 716-61-0
  • C9H12O4N2
  • C9H13N2O4
  • HOCH2CHNH2CHC6H4NO2OH
  • AMINE
  • Amino Alcohols
  • Asymmetric Synthesis
  • Organic Building Blocks
  • Optical Resolution
  • Chiral Building Blocks
  • for Resolution of Acids