Diphenylpiperidin-4-ylmethanol hydrochloride
Diphenylpiperidin-4-ylmethanol hydrochloride Basic information
- Product Name:
- Diphenylpiperidin-4-ylmethanol hydrochloride
- Synonyms:
-
- AZACYCLONOL HYDROCHLORIDE
- DIPHENYL-PIPERIDIN-4-YL-METHANOLHYDROCHLORIDE
- ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL, HYDROCHLORIDE
- alpha-(4-piperidyl)benzhydrolhydrochloride
- alpha,alpha-diphenyl-4-piperidinemethanohydrochloride
- alpha,alpha-diphenyl-4-piperidinemethanolhydrochloride
- frenquelhydrochloride
- gamma-pipradolhydrochloride
- CAS:
- 1798-50-1
- MF:
- C18H22ClNO
- MW:
- 303.83
- EINECS:
- 217-284-9
- Mol File:
- 1798-50-1.mol
Diphenylpiperidin-4-ylmethanol hydrochloride Chemical Properties
- Melting point:
- 270-281 °C
- form
- Crystalline Powder
- color
- White to off-white
- CAS DataBase Reference
- 1798-50-1(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi,T
- Risk Statements
- 36/37/38-25
- Safety Statements
- 24/25-45
- HazardClass
- IRRITANT
- HS Code
- 29333999
MSDS
- Language:English Provider:ACROS
Diphenylpiperidin-4-ylmethanol hydrochloride Usage And Synthesis
Chemical Properties
white to off-white crystalline powder
Originator
Frenquel,Merrell,US,1955
Manufacturing Process
A mixture of 26 g (0.1 mol) of α-(4-pyridyl)-benzhydrol, 1.5 g of platinum
oxide, and 250 ml of glacial acetic acid is shaken at 50-60°C under hydrogen
at a pressure of 40-50 lb/in2. The hydrogenation is complete in 2 to 3 hours.
The solution is filtered and the filtrate evaprated under reduced pressure. The
residue is dissolved in a mixture of equal parts of methanol and butanone and
0.1 mol of concentrated hydrochloric acid is added. The mixture is cooled and
filtered to give about 30 g of α-(4-piperidyl)benzhydrol hydrochloride, MP 283-
285°C, as a white, crystalline substance.
The free base is readily obtained from the hydrochloride salt by treatment
with ammonia and when so obtained has a melting point of 160-161°C.
brand name
Frenquel (Marion Merrell Dow).
Therapeutic Function
Tranquilizer
Diphenylpiperidin-4-ylmethanol hydrochlorideSupplier
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