IEM 1460 Chemical Properties

storage temp. 

Desiccate at RT

solubility 

Soluble to 100 mM in water and to 100 mM in DMSO

form 

solid

color 

white

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

IEM 1460 Usage And Synthesis

Description

IEM 1460 is an adamantine derivative that blocks both AMPA- and NMDA-type glutamate receptor (GluR) channels (IC₅₀ = 10 μM-0.1 mM). It is selective for Ca²⁺-permeable GluR channels, which lack the GluR2 R subunit, and has been used to identify Ca²⁺-permeable glutamate receptors in the brain.

Uses

IEM 1460 is an Adamantane derivative and open-channel blocker of AMPA currents.

Biological Activity

Voltage-dependent open-channel blocker of AMPA receptors. Displays selectivity between subtypes, blocking GluR2 subunit-lacking (Ca 2+ -permeable) receptors more potently than GluR2-containing receptors (IC 50 values are 2.6 and 1102 μ M respectively). Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo .

storage

Room temperature (desiccate)

IEM 1460(121034-89-7)Related Product Information

• IEM-1460 DIBROMIDE
• IEM 1460