ETHYL2-(4-HYDROXYPYRIMIDIN-5-YL)ACETATE Chemical Properties

Melting point:

155-156 °C

Density 

1.27±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

8.62±0.40(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2933599590

ETHYL2-(4-HYDROXYPYRIMIDIN-5-YL)ACETATE Usage And Synthesis

Synthesis

The ethanolic solution of sodium ethoxide was cooled to 0 °C under argon protection. Under continuous stirring, diethyl 2-formylsuccinate was slowly added. after 5 minutes, the corresponding formamidine acetate was added drop by drop while maintaining the condition of 0°C. Subsequently, the reaction mixture was warmed up to room temperature and stirred continuously for 3 days. After completion of the reaction, 5% aqueous hydrogen chloride solution was added and stirring was continued for 30 minutes. After addition of appropriate amount of water, ethanol was removed by distillation under reduced pressure at 30 °C. Finally, the precipitate was collected by filtration to afford the target product ethyl 4-hydroxy-5-pyrimidineacetate (Compound 1, where X = H, Me, Ph, SMe; Y = H, R1 = Et).

References

[1] Monatshefte fur Chemie, 2016, vol. 147, # 4, p. 767 - 773