Ethyl 2-chloro-6-methylpyridine-4-carboxylate, 97% Chemical Properties

Melting point:

65-67°C

Boiling point:

107°C/1.5mm

Density 

1?+-.0.06 g/cm3(Predicted)

Flash point:

107°C/1.5mm

storage temp. 

Inert atmosphere,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

-0.14±0.10(Predicted)

color 

White to Almost white

Safety Information

HS Code 

2933399990

Ethyl 2-chloro-6-methylpyridine-4-carboxylate, 97% Usage And Synthesis

Synthesis

Step 1: Synthesis of ethyl 2-chloro-6-methylisonicotinate (97). Concentrated sulfuric acid (2 mL) was added dropwise to a stirred solution of 2-chloro-6-methylpyridine-4-carboxylic acid (7.0 g, 40.79 mmol) in ethanol (70 mL) at 0 °C. Subsequently, the reaction mixture was heated to 80 °C and kept for 12 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under vacuum to remove the solvent. The concentrated residue was diluted with ethyl acetate and washed sequentially with water, sodium bicarbonate solution and saturated aqueous sodium chloride solution. The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated to give ethyl 2-chloro-6-methylisonicotinate (97) (7 g, 86% yield) as a white solid.

References

[1] Patent: US2010/249071, 2010, A1. Location in patent: Page/Page column 63-64
[2] Patent: WO2008/29371, 2008, A1. Location in patent: Page/Page column 41
[3] Patent: WO2009/24905, 2009, A1. Location in patent: Page/Page column 38-39; 49
[4] Patent: US2010/63108, 2010, A1. Location in patent: Page/Page column 16
[5] Patent: US2011/46170, 2011, A1. Location in patent: Page/Page column 17

Ethyl 2-chloro-6-methylpyridine-4-carboxylate, 97%(3998-88-7)Related Product Information

• RARECHEM AL BW 1436
• ETHYL 6-(TERT-BUTYL)-2-CHLORO-3-CYANOISONICOTINATE
• SPECS AO-801/41077570
• RARECHEM AL BW 1166
• Ethyl 2-chloro-6-methylpyridine-4-carboxylate, 97%
• ETHYL 2-CHLORO-3-CYANO-6-METHYL-5-NITROPYRIDINE-4-CARBOXYLATE
• ETHYL 2-CHLORO-3-CYANO-6-METHYLISONICOTINATE
• RARECHEM AL BW 0413
• ETHYL 2-(TERT-BUTYL)-3,6-DICHLORO-5-CYANOISONICOTINATE
• RARECHEM AL BW 2014