Coumarin 106 Chemical Properties

Melting point:

149 °C

Boiling point:

538.4±50.0 °C(Predicted)

Density 

1.32±0.1 g/cm3(Predicted)

solubility 

DMSO: Slightly soluble: 0.1-1 mg/ml

pka

6.38±0.20(Predicted)

form 

powder to crystal

color 

Light orange to Yellow to Green

λmax

375nm(Acetone)(lit.)

EPA Substance Registry System

1H,5H-Cyclopenta[3,4][1]benzopyrano[6,7,8-ij]quinolizin-12(9H)-one, 2,3,6,7,10,11-hexahydro- (41175-45-5)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

37/39-26

HS Code 

29322985

MSDS

• Language:English Provider:ACROS

Coumarin 106 Usage And Synthesis

Description

Coumarin 478 is a vital chemical compound used in biomedicine mainly for its anticancer properties. It has demonstrated potential in inhibiting tumor growth and metastasis, making it a valuable drug in the treatment of various types of cancers. Coumarin 478 shows promising results in clinical trials and is actively being researched for its effectiveness against specific cancer types.

Chemical Properties

yellow powder and chunks

Uses

Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC50=4.97 and Ki=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC50=4.56)[1][2].

References

[1] Patil SK, et al. Determination of ground and excited state dipole moments of dipolar laser dyes by solvatochromic shift method. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 5;123:117-26. DOI:10.1016/j.saa.2013.12.031
[2] Fallarero A, et al. Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. Pharmacol Res. 2008 Sep-Oct;58(3-4):215-21. DOI:10.1016/j.phrs.2008.08.001
[3] G.A. REYNOLDS  K. H D. New coumarin dyes with rigidized structure for flashlamp-pumped dye lasers[J]. Optics Communications, 1975, 13 3: Pages 222-225. DOI: 10.1016/0030-4018(75)90085-1
[4] EMMA ALEXANDER. Room temperature phosphorescence of coumarin 106 with direct triplet state excitation[J]. Dyes and Pigments, 2023, 217: Article 111389. DOI: 10.1016/j.dyepig.2023.111389

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