N-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propyl]-4-bromo-N-(3-dimethylamino-propyl)-benzamide Chemical Properties

Boiling point:

717.0±70.0 °C(Predicted)

Density 

1.31±0.1 g/cm3(Predicted)

pka

9.33±0.28(Predicted)

N-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propyl]-4-bromo-N-(3-dimethylamino-propyl)-benzamide Usage And Synthesis

Uses

CK0106023 is a potent and specific allosteric inhibitor of KSP with a Ki value of 12 nM, showing antitumor activity. CK0106023 causes mitotic arrest and growth inhibition in several tumor cell lines. CK0106023 exhibits antitumor activity in tumor-bearing mice[1][2].

References

[1] You-Ling Fan. End-capped polyarylene polyethers, articles made therefrom and process for preparing such polyarylene polyethers. EP0106023B1. 1988 March 30.
[2] Sakowicz R, et al. Antitumor activity of a kinesin inhibitor. Cancer Res. 2004 May 1;64(9):3276-80. DOI:10.1158/0008-5472.can-03-3839

N-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propyl]-4-bromo-N-(3-dimethylamino-propyl)-benzamide(336115-72-1)Related Product Information

• N-[1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propyl]-4-bromo-N-(3-dimethylamino-propyl)-benzamide
• 3-BENZYL-2-PROPYL-3H-QUINAZOLIN-4-ONE
• 3-METHYL-2-(1-METHYLAMINOETHYL)-3H-QUINAZOLIN-4-ONE