4-Bromoisatoic anhydride Chemical Properties

Density 

1.826

storage temp. 

2-8°C

form 

Pale cream, wooly, small crystalline flakes

pka

9.95±0.20(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

HS Code 

2934999090

4-Bromoisatoic anhydride Usage And Synthesis

Chemical Properties

White solid

Synthesis

7.1: Synthesis of 7-bromo-1H-benzo[d][1,3]oxazine-2,4-dione In a 250 mL round bottom flask, 5.0 g (23.1 mmol) of 2-amino-4-bromobenzoic acid was dissolved in 50 mL of anhydrous dioxane under nitrogen protection. The reaction mixture was cooled to 0 °C via an ice bath. 2.3 g (7.6 mmol) of triphosgene was added slowly and dropwise. Subsequently, the ice bath was replaced with an oil bath and the reaction mixture was refluxed for 16 hours. After completion of the reaction, it was cooled to room temperature, 100 mL of water was added, and the resulting precipitate was collected by filtration. The precipitate was washed with ether (3 x 25 mL) and then dried in an oven to give 5.6 g (23.1 mmol) of the target product as a beige powder in 100% yield. 1H NMR (DMSO-d6, 300 MHz) δ: 7.29 (d, J = 1.8 Hz, 1H), 7.41 (dd, J = 8.4 Hz, J = 1.8 Hz, 1H), 7.82 (d, J = 8.4 Hz, 1H), 11.81 (bs, 1H).

References

[1] Patent: US2011/251194, 2011, A1. Location in patent: Page/Page column 17
[2] Patent: WO2013/147711, 2013, A1. Location in patent: Page/Page column 158
[3] Patent: US2014/371199, 2014, A1. Location in patent: Paragraph 0584
[4] Beilstein Journal of Organic Chemistry, 2018, vol. 14, p. 2529 - 2536
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 17, p. 6928 - 6937

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