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4-Bromoisatoic anhydride

Product Name
4-Bromoisatoic anhydride
CAS No.
76561-16-5
Chemical Name
4-Bromoisatoic anhydride
Synonyms
4-Bromo-isatoic anhydride;4-Bromoisatoicanhydride97%;Isatoic anhydride, 4-bromo-;4-Bromoisatoic anhydride 97%;7-bromo-1H-3,1-benzoxazine-2,4-dione;7-Bromo-2H-3,1-benzoxazine-2,4(1H)-dione;7-Bromo-1H-benzo[d][1,3]oxazine-2,4-dione;2H-3,1-Benzoxazine-2,4(1H)-dione, 7-bromo-;7-bromo-2H-benzo[d][1,3]oxazine-2,4(1H)-dione;7-bromo-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione
CBNumber
CB61856783
Molecular Formula
C8H4BrNO3
Formula Weight
242.03
MOL File
76561-16-5.mol
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4-Bromoisatoic anhydride Property

Density 
1.826
storage temp. 
2-8°C
form 
Pale cream, wooly, small crystalline flakes
pka
9.95±0.20(Predicted)
Appearance
Off-white to light yellow Solid
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B684648
Product name
4-Bromoisatoicanhydride
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140464
Product name
7-Bromo-1H-benzo[d][1,3]oxazine-2,4-dione
Packaging
1g
Price
$70
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140464
Product name
7-Bromo-1H-benzo[d][1,3]oxazine-2,4-dione
Packaging
2g
Price
$100
Updated
2021/12/16
Apolloscientific
Product number
OR400015
Product name
4-Bromoisatoicanhydride
Purity
97%
Packaging
1g
Price
$57
Updated
2021/12/16
SynQuest Laboratories
Product number
4H26-9-02
Product name
4-Bromoisatoic anhydride
Purity
97%
Packaging
1g
Price
$63
Updated
2021/12/16
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4-Bromoisatoic anhydride Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

32315-10-9

20776-50-5

76561-16-5

7.1: Synthesis of 7-bromo-1H-benzo[d][1,3]oxazine-2,4-dione In a 250 mL round bottom flask, 5.0 g (23.1 mmol) of 2-amino-4-bromobenzoic acid was dissolved in 50 mL of anhydrous dioxane under nitrogen protection. The reaction mixture was cooled to 0 °C via an ice bath. 2.3 g (7.6 mmol) of triphosgene was added slowly and dropwise. Subsequently, the ice bath was replaced with an oil bath and the reaction mixture was refluxed for 16 hours. After completion of the reaction, it was cooled to room temperature, 100 mL of water was added, and the resulting precipitate was collected by filtration. The precipitate was washed with ether (3 x 25 mL) and then dried in an oven to give 5.6 g (23.1 mmol) of the target product as a beige powder in 100% yield. 1H NMR (DMSO-d6, 300 MHz) δ: 7.29 (d, J = 1.8 Hz, 1H), 7.41 (dd, J = 8.4 Hz, J = 1.8 Hz, 1H), 7.82 (d, J = 8.4 Hz, 1H), 11.81 (bs, 1H).

References

[1] Patent: US2011/251194, 2011, A1. Location in patent: Page/Page column 17
[2] Patent: WO2013/147711, 2013, A1. Location in patent: Page/Page column 158
[3] Patent: US2014/371199, 2014, A1. Location in patent: Paragraph 0584
[4] Beilstein Journal of Organic Chemistry, 2018, vol. 14, p. 2529 - 2536
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 17, p. 6928 - 6937

4-Bromoisatoic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromoisatoic anhydride Suppliers

China 85 Germany 1 India 1 United Kingdom 2 United States 11 Global 100
Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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China
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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China
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Shanghai Longsheng chemical Co.,Ltd.
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021-58099652-8005 13585536065
Fax
021-58099609
Email
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China
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Shandong Xiya Chemical Co., Ltd
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4009903999 13355009207
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0539-6365991
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3007715519@qq.com
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China
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Chengdu HappySyn Pharmaceutical Technology Co., Ltd.
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028-85114309 18982182443
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yangli@happysyn.com
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Chengdu Forest Science and Technology Development Co., Ltd.
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China
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Shanghai T&W Pharmaceutical Co., Ltd.
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+86 21 61551611
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+86 21 50676805
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China
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66113011 17798518460
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(1)02557626880
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China
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9ding chemical ( Shanghai) Limited
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4009209199
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