Basic information Safety Supplier Related

Quinestrol

Basic information Safety Supplier Related

Quinestrol Basic information

Product Name:
Quinestrol
Synonyms:
  • 17-alpha-ethinylestradiol3-cyclopentylether
  • 3-(cyclopentyloxy)-(17-alpha)-19-norpregna-5(10)-trien-20-yn-17-ol
  • 3-(cyclopentyloxy)-19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yn-17-ol
  • 5(10)-trien-20-yn-17-ol,3-(cyclopentyloxy)-19-nor-17-alpha-pregna-3
  • eecpe
  • eston
  • 17ALPHA-ETHYLNYL-1,3,5[10]ESTRATRIENE-3,17BETA-DIOL 3-CYCLOPENTYL ETHER
  • 17a-ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-cyclopentyl ether
CAS:
152-43-2
MF:
C25H32O2
MW:
364.52
EINECS:
205-803-1
Product Categories:
  • BACTROBAN
Mol File:
152-43-2.mol
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Quinestrol Chemical Properties

Melting point:
107-108°
alpha 
D25 +5° (c = 0.5 in dioxane)
Boiling point:
435.69°C (rough estimate)
Density 
1.0693 (rough estimate)
refractive index 
1.4480 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
13.10±0.40(Predicted)
form 
Solid
color 
White to Off-White
Merck 
14,8055
CAS DataBase Reference
152-43-2(CAS DataBase Reference)
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Safety Information

Hazard Codes 
T
Risk Statements 
45-61-20/21/22-46
Safety Statements 
53-22-36/37/39-45
WGK Germany 
3
RTECS 
RC8948000

MSDS

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Quinestrol Usage And Synthesis

Description

Quinestrol is a synthetic estrogen that is effective in hormone replacement therapy. It is a 3-cyclopentyl ether of ethynyl estradiol. After gastrointestinal absorption, it is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol. Quinestrol has found limited use in suppressing lactation in postpartum women and, in combination with synthetic progestogens, as contraceptive therapy, although additional studies are needed for both applications.

Uses

antibacterial, antimycoplasmal, isoleucyl-tRNA synthetase inhibitor

Uses

Quinestrol is an estrogen-like compound.

Definition

ChEBI: Quinestrol is a 17-hydroxy steroid and a terminal acetylenic compound. It has a role as a xenoestrogen. It is functionally related to a 17beta-estradiol.

brand name

Estrovis (Parke-Davis).

References

[1]. baumgardner sb, condrea h, daane ta, et al. replacement estrogen therapy for menopausal vasomotor flushes. comparison of quinestrol and conjugated estrogens. obstet gynecol. 1978 apr;51(4):445-52.
[2]. skouby, s.o. criteria for the selection of an optimal estrogen replacement. gynecological endocrinology 15, 60-67 (2001).
[3]. li j, chen f, li c,et al. quinestrol induces spermatogenic apoptosis in vivo via increasing pro-apoptotic proteins in adult male mice. tissue cell. 2014 oct;46(5):318-25.
[4]. li j, chen f, chen y, et al. mitochondrial- and fas-l-mediated pathways involved in quinestrol induced spermatogenic apoptosis in adult rat testes. toxicol mech methods. 2014 dec;24(9):609-15.

Quinestrol Preparation Products And Raw materials

Raw materials

TetrahydrofuranCyclopentyl bromide

QuinestrolSupplier

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
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021-61259108 18621169109
Email
market03@meryer.com
TCI (Shanghai) Development Co., Ltd.
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021-67121386
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Sales-CN@TCIchemicals.com
LGM Pharma
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1-(800)-881-8210
Email
inquiries@lgmpharma.com
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
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Quinestrol(152-43-2)Related Product Information