Pristinamycin IA
Pristinamycin IA Basic information
- Product Name:
- Pristinamycin IA
- Synonyms:
-
- N-[(3-Hydroxy-2-pyridinyl)carbonyl]-L-threonyl-(2R)-2-aMinobutanoyl-L-prolyl-4-(diMethylaMino)-N-Methyl-L-phenylalanyl-(2S)-4-oxo-2-piperidinecarbonyl-(2S)-2-phenylglycine (6-13)-lactone
- NSC 92554
- PA 114B
- PristinaMycin P 1
- Ostreogrycin B, PristinaMycin IA, StreptograMin B, Syncothrecin B1, Synergistin B, VernaMycin Balpha, VirginiaMycin 1A, NSC 125176, 14725-1, PA 114B, RP 12535
- VirginiaMycin B
- Pristinamycin IA, >95%
- mikamycin B
- CAS:
- 3131-03-1
- MF:
- C45H54N8O10
- MW:
- 866.96
- Product Categories:
-
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 3131-03-1.mol
Pristinamycin IA Chemical Properties
- Melting point:
- 198°
- alpha
- D22 -57.5° (c = 0.25 in ethanol)
- Boiling point:
- 780.3°C (rough estimate)
- Density
- 1.1881 (rough estimate)
- refractive index
- 1.6910 (estimate)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- pKa 7.20±0.05(H2O,t =25,I=0.2(LiClO4)) (Uncertain)
- color
- Pale Yellow
Pristinamycin IA Usage And Synthesis
Uses
Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a syngergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Viriginiamycin B acts a syngergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.
Uses
One of the two major components of Pristinamycin (Pristinamycin IA and Pristinamycin IIA (or Virginiamycin M1-V673810).
Definition
ChEBI: A cyclodepsipeptide that is (together with pristinamycin IIA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organis s including methicillin-resistant Staphylococcus aureus.
Contact allergens
Pristinamycin is a systemic antibiotic of the synergistins/ streptogramins class, composed of two subunits: pristinamycin IA and pristinamycin IIA. It induces several types of drug reactions such as maculo-papular exanthema, systemic dermatitis, or acute generalized exanthematous pustulosis. Some patients have been previously skin-sensitized by virginiamycin. Crossreactivity is expected to virginiamycin and to the associated dalfopristin and quinupristin.
Pristinamycin IASupplier
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