4-BROMO-3-METHYL-BENZALDEHYDE Chemical Properties

Melting point:

114-116℃

Boiling point:

262℃

Density 

1.490

Flash point:

96℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Acetonitrle (Sparingly), Chloroform (Slightly), DMSO (Sparingly), Methanol (Spar

form 

Oil

color 

Colourless to White

Stability:

Air Sensitive

InChI

InChI=1S/C8H7BrO/c1-6-4-7(5-10)2-3-8(6)9/h2-5H,1H3

InChIKey

YBXGUHGVNUFFJU-UHFFFAOYSA-N

SMILES

C(=O)C1=CC=C(Br)C(C)=C1

Safety Information

HS Code 

2913000090

4-BROMO-3-METHYL-BENZALDEHYDE Usage And Synthesis

Uses

4-Bromo-3-methylbenzaldehyde can be involved in determining conformational landscape of σ and π coupling Using para-phenylene and "Aviram-Ratner" bridges. Tetrahydroquinoline derivatives as opioid receptor antagonists.

Synthesis

Step 3: Preparation of 4-bromo-3-methylbenzaldehyde (4-Bromo-3-methylphenyl)methanol (420 mg, 2.09 mmol) was dissolved in dichloromethane (6 mL) at room temperature. Subsequently, manganese dioxide (1.82 g, 20.9 mmol) was added to this solution. The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the insoluble solid was removed by filtration and the filtrate was concentrated under reduced pressure to afford 4-bromo-3-methylbenzaldehyde (372 mg, 89% yield) as an oil.

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 13, p. 3774 - 3789
[2] Tetrahedron Letters, 2007, vol. 48, # 52, p. 9144 - 9147
[3] Patent: US2013/131016, 2013, A1. Location in patent: Paragraph 0191
[4] Organic and Biomolecular Chemistry, 2011, vol. 9, # 11, p. 4276 - 4286
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 10, p. 3973 - 4001

4-BROMO-3-METHYL-BENZALDEHYDE(78775-11-8)Related Product Information

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• AKOS BBS-00001986
• SPECS AE-562/12222711