4-(4-Chlorophenyl)cyclohexanecarboxylic acid Chemical Properties

Melting point:

250 °C

Boiling point:

387.1±42.0 °C(Predicted)

Density 

1.225±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

4.80±0.10(Predicted)

Appearance

White to off-white Solid

CAS DataBase Reference

95233-37-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-36

Safety Statements 

26-36/37/39-22

Hazard Note 

Irritant

4-(4-Chlorophenyl)cyclohexanecarboxylic acid Usage And Synthesis

Uses

4-(4-Chlorophenyl)cyclohexanecarboxylic Acid is a reactant used in the synthesis of novel hydrazone derivatives as antimicrobial agents.

Synthesis

General procedure for the synthesis of 4-(4-chlorophenyl)cyclohexane-1-carboxylic acid from methyl 4-(4-chlorophenyl)cyclohexane-1-carboxylate: 4-(4-chlorophenyl)cyclohexane-1-carboxylic acid methyl ester (10.08 g, 0.04 mol) was added to a 250 mL triple-necked vial, followed by methanol (80 mL) and water (20 mL). Lithium hydroxide (3.60 g, 0.15 mol) was added to the reaction mixture and the reaction was stirred at room temperature for 5 hours. After the reaction was completed, the pH of the reaction solution was adjusted to 1 with 1 N hydrochloric acid and stirring was continued for 30 minutes. The precipitated solid was collected by filtration and the filter cake was washed with water to pH 5 to obtain the crude product. The crude product was dissolved in 60 mL of ethanol and recrystallized, resulting in 8.50 g of white solid product with 89% yield and 99.17% purity.

References

[1] Patent: CN104628555, 2016, B. Location in patent: Paragraph 0036; 0037; 0045

4-(4-Chlorophenyl)cyclohexanecarboxylic acid(95233-37-7)Related Product Information

• Molasses
• 4-Chlorophenyl isocyanate
• Cyclohexylbenzene
• Chlorodimethylphenylsilane
• Chlorodiphenylmethane
• Triphenylmethyl Chloride
• 1-(4-chlorophenyl)cyclohexanecarboxylic acid
• TRANS-4-(4-CHLOROPHENYL)CYCLOHEXANECARBOXYLIC ACID,4-(4-Chlorophenyl)cyclohexanecarboxylic acid
• Tazarotene
• 1-(3-CHLOROPHENYL)CYCLOHEXANECARBOXYLIC ACID
• 1-AMINO-4-(4-CHLOROPHENYL)CYCLOHEXANECARBOXYLIC ACID
• 4-(4-Chlorophenyl)cyclohexanecarboxylic acid