(2E)-3-(1H-Imidazole-4-yl)propenoic acid Chemical Properties

Melting point:

225 °C

Boiling point:

456.9±20.0 °C(Predicted)

Density 

1.430±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF: 3 mg/ml; DMSO: 15 mg/ml; PBS (pH 7.2): 0.3 mg/ml

form 

powder to crystal

pka

3.55±0.10(Predicted)

color 

White to Almost white

Safety Information

HS Code 

2933.29.9000

(2E)-3-(1H-Imidazole-4-yl)propenoic acid Usage And Synthesis

Uses

trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function[1].

Definition

ChEBI: The trans-isomer of urocanic acid.

IC 50

Human Endogenous Metabolite

References

[1] J Uksila, et al. Trans-urocanic acid, a natural epidermal constituent, inhibits human natural killer cell activity in vitro. Exp Dermatol. 1994 Apr;3(2):61-5. DOI:10.1111/j.1600-0625.1994.tb00048.x
[2] Kazuyo Kaneko, et al. cis-Urocanic acid enhances prostaglandin E2 release and apoptotic cell death via reactive oxygen species in human keratinocytes. J Invest Dermatol. 2011 Jun;131(6):1262-71. DOI:10.1038/jid.2011.37

(2E)-3-(1H-Imidazole-4-yl)propenoic acid(3465-72-3)Related Product Information

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