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CYTOCHALASIN C

Basic information Safety Supplier Related

CYTOCHALASIN C Basic information

Product Name:
CYTOCHALASIN C
Synonyms:
  • (11)cytochalasa-5,13,19-triene-1,17-dione,21-(acetoxy)-7,18-dihydroxy-16,18-di
  • (7s,13e,16s,18r,19e,21r)-methyl-10-phenyl
  • CYTOCHALASIN C
  • cytochalasin C from metarrhizium anisopliae
  • cytochalasin-C from metarrhizium*anisopliae
  • CYTOCHALASIN C(RG)
  • 7(S),18-dihydroxy-16(S),18(R)-dimethyl-10-phenyl[11]cytochalasa-5,13(E),19(E)-triene-1,17-dione 21(R)-acetate
  • CYTOCHALASIN C FROM METARRHIRIUM ANISOPL IAE
CAS:
22144-76-9
MF:
C30H37NO6
MW:
507.62
EINECS:
244-803-6
Product Categories:
  • antibiotic
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Other
Mol File:
22144-76-9.mol
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CYTOCHALASIN C Chemical Properties

Melting point:
260-264°C
Boiling point:
595.84°C (rough estimate)
Density 
1.1764 (rough estimate)
refractive index 
1.6310 (estimate)
storage temp. 
−20°C
solubility 
methylene chloride: 5 mg/mL, clear, colorless
form 
White to off-white powder.
pka
11.95±0.70(Predicted)
color 
White to off-white
BRN 
1613194
LogP
3.250 (est)
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Safety Information

Hazard Codes 
T+,T
Risk Statements 
26/27/28-63
Safety Statements 
28-36/37-45
RIDADR 
UN 1544 6.1/PG 2
WGK Germany 
3
RTECS 
HA5300500
10
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
29337900
Toxicity
mouse,LD,intraperitoneal,> 100mg/kg (100mg/kg),Chemical and Pharmaceutical Bulletin. Vol. 21, Pg. 2268, 1973.

MSDS

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CYTOCHALASIN C Usage And Synthesis

Chemical Properties

White solid

Uses

Cytochalasin C, a fungal metabolite, is an analog of Cytochalasin D (C998700), an anti-hypertensive drug acting on human intestinal epithelial caco-2 cells. Also has activity in HMG-CoA reductase inhibitors used in the lowering of cholesterol. Actin inhibitor, actin polymerization inhibitor affecting cell movement, growth, phagocytosis and even secretion.

Uses

Cytochalasin C is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic changes in animals and plants. The cytochalasins act by disrupting actin microfilaments and these effects are most noticeable by the inhibition of cell division.

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