3-[[5-(2,3-DICHLOROPHENYL)-1H-TETRAZOL-1-YL]METHYL]PYRIDINE HYDROCHLORIDE
3-[[5-(2,3-DICHLOROPHENYL)-1H-TETRAZOL-1-YL]METHYL]PYRIDINE HYDROCHLORIDE Basic information
- Product Name:
- 3-[[5-(2,3-DICHLOROPHENYL)-1H-TETRAZOL-1-YL]METHYL]PYRIDINE HYDROCHLORIDE
- Synonyms:
-
- 3-[[5-(2,3-DICHLOROPHENYL)-1H-TETRAZOL-1-YL]METHYL]PYRIDINE HYDROCHLORIDE
- A 438079 HYDROCHLORIDE
- A 438079
- 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine
- 3-{[5-(2,3-DICHLOROPHENYL)-1H-1,2,3,4-TETRAZOL-1-YL]METHYL}PYRIDINE
- Pyridine, 3-[[5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl]methyl]-
- A 438079 HCI
- A 438079 hydrochlori
- CAS:
- 899507-36-9
- MF:
- C13H9Cl2N5
- MW:
- 306.15
- Mol File:
- 899507-36-9.mol
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3-[[5-(2,3-DICHLOROPHENYL)-1H-TETRAZOL-1-YL]METHYL]PYRIDINE HYDROCHLORIDE Chemical Properties
- storage temp.
- Desiccate at RT
- solubility
- Soluble in DMSO
- form
- Powder
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3-[[5-(2,3-DICHLOROPHENYL)-1H-TETRAZOL-1-YL]METHYL]PYRIDINE HYDROCHLORIDE Usage And Synthesis
Uses
3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine is a 1-Benzyl-5-aryltetrazole derivative and potential antagonists for the P2X7 receptor.
Biological Activity
Competitive P2X 7 receptor antagonist (pIC 50 = 6.9 for the inhibition of Ca 2+ influx in the human recombinant P2X 7 cell line). Devoid of activity at other P2 receptors (IC 50 >> 10 μ M). Possesses antinociceptive activity in models of neuropathic pain in vivo .
3-[[5-(2,3-DICHLOROPHENYL)-1H-TETRAZOL-1-YL]METHYL]PYRIDINE HYDROCHLORIDESupplier
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