O-DesMethyl TraMadol Hydrochloride
O-DesMethyl TraMadol Hydrochloride Basic information
- Product Name:
- O-DesMethyl TraMadol Hydrochloride
- Synonyms:
-
- 2-[(rel-1R, 2R)(DiMethylaMino)Methyl]-1-(M-hydroxyphenyl)cyclohexanol Hydrochloride
- 3-[(rel-1R,2R)2-[(DiMethylaMino)Methyl]-1-hydroxycyclohexyl]phenol Hydrochloride
- O-DesMethyl TraMadol Hydrochloride (1.0 Mg/ML in Methanol)
- O-Desmethyl-cis-tramadol (hydrochloride) (CRM)
- O-Desmethyl-cis-tramadol (hydrochloride)
- (±)-(cis)-O-Desmethyl cis-tramadol hydrochloride
- 2-[(Dimethylamino)methyl]-1-(3-hydroxyphenyl)cyclohexanol Hydrochloride
- TraMadol Hydrochloride IMpurity-D(EP)
- CAS:
- 185453-02-5
- MF:
- C15H24ClNO2
- MW:
- 285.80956
- Product Categories:
-
- Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Mol File:
- 185453-02-5.mol
O-DesMethyl TraMadol Hydrochloride Chemical Properties
- Melting point:
- 219-221?C
- storage temp.
- -20°C Freezer
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to off-white
O-DesMethyl TraMadol Hydrochloride Usage And Synthesis
Description
O-Desmethyl-cis-tramadol (hydrochloride) (CRM) (Item No. 18751) is a certified reference material that is structurally categorized as an opioid. It is the main metabolite of cis-tramadol (Item Nos. ISO60149 | 15919). O-Desmethyl-cis-tramadol has ~400-500-fold higher affinity for μ-opioid receptors than the parent compound. However, O-desmethyl-cis-tramadol poorly suppresses the human serotonin transporter, unlike cis-tramadol. This product is intended for research and forensic applications.
Chemical Properties
White Solid
Uses
A metabolite of Tramadol, an analgesic.
References
[1] MADELEINE RAMONA VOLZ Bjoern M. Development of a non-radioactive mass spectrometry-based binding assay at the μ-opioid receptor and its application for the determination of the binding affinities of 17 opiates/opioids as well as of the designer opioid isotonitazene and five further 2-benzylbenzimidazoles[J]. Analytica Chimica Acta, 2022, 1219: Article 339978. DOI: 10.1016/j.aca.2022.339978
[2] ATSUSHI NAKAMURA. Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice.[J]. Psychopharmacology, 2008, 200 3: 307-316. DOI: 10.1007/s00213-008-1180-1
[3] W. WU. Metabolism of the analgesic drug, tramadol hydrochloride, in rat and dog[J]. Xenobiotica, 2001, 31 1: 423-441. DOI: 10.1080/00498250110057378