6-Boc-2-oxo-6-aza-spiro[3.4]octane Chemical Properties

Boiling point:

331.8±35.0 °C(Predicted)

Density 

1.14±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

-0.80±0.20(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C12H19NO3/c1-11(2,3)16-10(15)13-5-4-12(8-13)6-9(14)7-12/h4-8H2,1-3H3

InChIKey

WQPZESPYNGQLQA-UHFFFAOYSA-N

SMILES

C1C2(CCN(C(OC(C)(C)C)=O)C2)CC1=O

Safety Information

HS Code 

2933998090

6-Boc-2-oxo-6-aza-spiro[3.4]octane Usage And Synthesis

Synthesis

1.21 mol) and zinc powder (Zn, 79.1 g, 1.21 mol). The reaction mixture was stirred at room temperature for 8 hours. After completion of the reaction, the mixture was treated with distilled water (H2O) and extracted with ethyl acetate (EtOAc). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by fast column chromatography (silica gel, eluent: petroleum ether to 25% ethyl acetate in petroleum ether solution) to afford the target product R-5 (19 g, 69% yield).

References

[1] Patent: US2014/45813, 2014, A1. Location in patent: Paragraph 0113
[2] Patent: US2014/275014, 2014, A1. Location in patent: Paragraph 0128; 0129; 0132
[3] Patent: WO2015/116485, 2015, A1. Location in patent: Page/Page column 24; 25

6-Boc-2-oxo-6-aza-spiro[3.4]octane(203661-71-6)Related Product Information

• 2,2-Dimethyl-5-(hydroxymethyl)-1,3-dixoane
• tert-butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate