2-BROMO-6-CHLOROBENZYL BROMIDE Chemical Properties

Melting point:

62-64°C

Boiling point:

283.4±25.0 °C(Predicted)

Density 

1.93g/ml

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

Light brown to off-white Solid

Safety Information

RIDADR 

UN1759

HazardClass 

8

HS Code 

2903998090

2-BROMO-6-CHLOROBENZYL BROMIDE Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-bromo-6-chlorobenzyl bromide (compound [5-2]) from 2-bromo-6-chlorotoluene: 2-bromo-6-chlorotoluene (1.58 g) was dissolved in 15 mL of carbon tetrachloride, and N-bromosuccinimide (1.63 g) and 2,2'-azino-bis (isobutyronitrile) (125 mg) were added. The reaction mixture was heated to reflux for 24 hours. After completion of the reaction, the reaction was quenched with water and the mixture was extracted with chloroform. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and the filtrate concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to afford 2-bromo-6-chlorobenzyl bromide (2.16 g) as a white solid.1H-NMR (400 MHz, CDCl3) δ: 7.51 (1H, d, J = 8.1 Hz), 7.37 (1H, d, J = 8.1 Hz), 7.11 (1H, d, J = 8.1 Hz), 4.80 (2H, s) .

References

[1] Organic and Biomolecular Chemistry, 2012, vol. 10, # 31, p. 6404 - 6409
[2] Journal of Medicinal Chemistry, 1981, vol. 24, # 4, p. 382 - 389
[3] Patent: US4259349, 1981, A
[4] Journal of the American Chemical Society, 2008, vol. 130, # 45, p. 15157 - 15166
[5] Journal of the American Chemical Society, 2011, vol. 133, # 24, p. 9282 - 9285