VeltuzuMab
VeltuzuMab Basic information
- Product Name:
- VeltuzuMab
- Synonyms:
-
- VeltuzuMab
- Research Grade Veltuzumab(DHC90711)
- Research Grade Veltuzumab
- CAS:
- 728917-18-8
- MW:
- 0
- Mol File:
- Mol File
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VeltuzuMab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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VeltuzuMab Usage And Synthesis
Uses
Veltuzumab (IMMU-106) is a humanized anti-CD20 monoclonal antibody. Veltuzumab has low EC50 value of 0.08-0.09 μg/mL in the Daudi cell line. Veltuzumab can be used for the research of cancer including non-Hodgkin lymphoma (NHL)[1].
in vivo
Veltuzumab (i.v. or s.c.; 5, 20 and 60 μg; single) can control tumor growth or deplete circulating or sessile B cells at low doses in mouse models of intraperitoneal and subcutaneous doses[1].
Veltuzumab (i.p.; 0.05-35 μg) are significantly effective in vivo[1].
| Animal Model: | Lymphoma xenograft model[1] |
| Dosage: | 5, 20 and 60 μg |
| Administration: | intraperitoneal and subcutaneous, single |
| Result: | Showed low dose of 0.05 μg increased the MST. |
| Animal Model: | SCID mice[1] |
| Dosage: | 0.5, 0.25, 0.1, or 0.05 μg; 35, 3.5, 0.35, or 0.035 μg |
| Administration: | intraperitoneal, single |
| Result: | Improved significantly survival. |
References
[1] David M Goldenberg, et al. Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody. Blood DOI:10.1182/blood-2008-07-168146
VeltuzuMabSupplier
NCE Biomedical Co.,Ltd.
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- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
LETOPHARM LIMITED
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- +86-21-5821 5861
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SPIRO PHARMA
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- eric_feng1954@126.com
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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Shanghai Han-Xiang Chemical Co., Ltd.
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- 15971444841
- amber@biochempartner.com