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BMX-IN-1

Basic information Safety Supplier Related

BMX-IN-1 Basic information

Product Name:
BMX-IN-1
Synonyms:
  • 6]naphthyridin-1(2H)-yl)phenyl)acrylamide
  • BMX KINASE INHIBITOR;N-(2-METHYL-5-(9-(4-(METHYLSULFONAMIDO)PHENYL)-2-OXOBENZO[H][1;6]NAPHTHYRIDIN-1(2H)-YL)PHENYL)ACRYLAMIDE
  • N-(2-methyl-5-(9-(4-(methylsulfonamido)phenyl)-2-oxobenzo[h][1
  • BMX kinase inhibitor
  • BMX-IN-1
  • N-(2-Methyl-5-(9-(4-(MethylsulfonaMido)phenyl)-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)phenyl)acrylaMide
  • N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide
  • henyl]-
CAS:
1431525-23-3
MF:
C29H24N4O4S
MW:
524.59
Mol File:
1431525-23-3.mol
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BMX-IN-1 Chemical Properties

Density 
1.397±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥5.25 mg/mL in DMSO
form 
solid
pka
7.77±0.10(Predicted)
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BMX-IN-1 Usage And Synthesis

Description

BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX; IC50 = 8 nM) that targets Cys496 in the BMX ATP binding domain. It additionally targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent for inhibition of Blk, JAK3, EGFR, Itk, or Tec activity. BMX-IN-1 was shown to inhibit the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with a GI50 value of 25 nM. Antiproliferative activity was also observed in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI50s = 2.54, 4.38, 5.37, and 2.46 μM, respectively).

target

BMX Kinase

storage

Store at -20°C

BMX-IN-1Supplier

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