Basic information Safety Supplier Related

PF 06465469 Discontinued See A191400

Basic information Safety Supplier Related

PF 06465469 Discontinued See A191400 Basic information

Product Name:
PF 06465469 Discontinued See A191400
Synonyms:
  • PF 06465469 Discontinued See A191400
  • (R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-aMino-1H-pyrazolo[3,4-d]pyriMidin-3-yl]-N-(4-isopropyl-5-Methylphenyl)benzaMide
  • PF 06465469
  • 3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide
  • (R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide
  • Benzamide, 3-[4-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-
  • PF06465469,PF 06465469
  • 3-[4-amino-1-[(3R)-1-prop-2-enoyl-3-piperidyl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-3-methyl-phenyl)benzamide
CAS:
1407966-77-1
MF:
C30H33N7O2
MW:
523.63
Product Categories:
  • Aromatics, Heterocycles, Inhibitors, Pfizer Compounds, Pharmaceuticals, Intermediates & Fine Chemicals
  • Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:
1407966-77-1.mol
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PF 06465469 Discontinued See A191400 Chemical Properties

Melting point:
209-212°C
Boiling point:
730.2±60.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL, clear
pka
12.83±0.70(Predicted)
form 
powder
color 
white to beige
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
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PF 06465469 Discontinued See A191400 Usage And Synthesis

Chemical Properties

Beige Solid

Uses

PF 06465469 is a covalent Inhibitors of Interleukin-2 Inducible T Cell Kinase (Itk) with nanomolar potency in a whole-blood assay.

Uses

(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-5-methylphenyl)benzamide is a potential covalent inhibitor of Interleukin-2 Inducible T Cell KInase (Itk). Itk is a member of the TEC-kinase family and is associated with the induction of T cell proliferation and drives cytokines through NFATc.

storage

Store at +4°C

PF 06465469 Discontinued See A191400Supplier

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