PF 06465469 Discontinued See A191400
PF 06465469 Discontinued See A191400 Basic information
- Product Name:
- PF 06465469 Discontinued See A191400
- Synonyms:
-
- PF 06465469 Discontinued See A191400
- (R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-aMino-1H-pyrazolo[3,4-d]pyriMidin-3-yl]-N-(4-isopropyl-5-Methylphenyl)benzaMide
- PF 06465469
- 3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide
- (R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide
- Benzamide, 3-[4-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-
- PF06465469,PF 06465469
- 3-[4-amino-1-[(3R)-1-prop-2-enoyl-3-piperidyl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-3-methyl-phenyl)benzamide
- CAS:
- 1407966-77-1
- MF:
- C30H33N7O2
- MW:
- 523.63
- Product Categories:
-
- Aromatics, Heterocycles, Inhibitors, Pfizer Compounds, Pharmaceuticals, Intermediates & Fine Chemicals
- Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File:
- 1407966-77-1.mol
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PF 06465469 Discontinued See A191400 Chemical Properties
- Melting point:
- 209-212°C
- Boiling point:
- 730.2±60.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL, clear
- pka
- 12.83±0.70(Predicted)
- form
- powder
- color
- white to beige
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PF 06465469 Discontinued See A191400 Usage And Synthesis
Chemical Properties
Beige Solid
Uses
PF 06465469 is a covalent Inhibitors of Interleukin-2 Inducible T Cell Kinase (Itk) with nanomolar potency in a whole-blood assay.
Uses
(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-5-methylphenyl)benzamide is a potential covalent inhibitor of Interleukin-2 Inducible T Cell KInase (Itk). Itk is a member of the TEC-kinase family and is associated with the induction of T cell proliferation and drives cytokines through NFATc.
storage
Store at +4°C
PF 06465469 Discontinued See A191400Supplier
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